| Covariation in individuals' sensitivities to bitter compounds: evidence supporting multiple receptor/transduction mechanisms. | |
| | |
MedLine Citation:
|
PMID: 11521845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
People vary widely in their sensitivities to bitter compounds, but the intercorrelation of these sensitivities is unknown. Our goal was to investigate correlations as a function of individual sensitivities to several bitter compounds representative of different chemical classes and, from these correlations, infer the number and variety of potential bitterness transduction systems for these compounds. Twenty-six subjects rated and ranked quinine HCl, caffeine, (-)-epicatechin, tetralone, L-phenylalanine, L-tryptophan, magnesium sulfate, urea, sucrose octaacetate (SOA), denatonium benzoate, and n-propylthiouracil (PROP) for bitterness. By examining individual differences, ratings and rankings could be grouped into two general clusters--urea/phenylalanine/tryptophan/epicatechin, and quinine/caffeine/SOA/denatonium benzoate/tetralone/magnesium sulfate-none of which contained PROP. When subjects were grouped into the extremes of sensitivity to PROP, a significant difference was found in the bitterness ratings, but not in the rankings. Therefore, there are also subjects who possess diminished absolute sensitivity to bitter stimuli but do not differ from other subjects in their relative sensitivities to these compounds. |
| | |
Authors:
|
J F Delwiche; Z Buletic; P A Breslin |
Related Documents
:
|
12664765 - Suicide in the highlands of scotland. 8975995 - Acoustic reflex monitoring during the presentation of 1000 clicks at high repetition ra... 20170265 - The associations between infant homicide, homicide, and suicide rates: an analysis of w... 6653385 - The day-to-day criminality of heroin addicts in baltimore--a study in the continuity of... 19571815 - Combining hand techniques with electric pumping increases milk production in mothers of... 21245905 - Predicting live birth, preterm delivery, and low birth weight in infants born from in v... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Perception & psychophysics Volume: 63 ISSN: 0031-5117 ISO Abbreviation: Percept Psychophys Publication Date: 2001 Jul |
Date Detail:
|
Created Date: 2001-08-27 Completed Date: 2001-09-27 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0200445 Medline TA: Percept Psychophys Country: United States |
Other Details:
|
Languages: eng Pagination: 761-76 Citation Subset: IM |
Affiliation:
|
Ohio State University, Columbus, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Female Humans Individuality* Male Propylthiouracil Reference Standards Reference Values Taste Buds / physiology* Taste Threshold / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
F32 DC00384-02/DC/NIDCD NIH HHS; R29 DC02995/DC/NIDCD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
51-52-5/Propylthiouracil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of different life-cycle impact assessment methods for aquatic ecotoxicity.
Next Document: Cross-modal attentional deficits in processing tactile stimulation.