Document Detail


Covariation in individuals' sensitivities to bitter compounds: evidence supporting multiple receptor/transduction mechanisms.
MedLine Citation:
PMID:  11521845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
People vary widely in their sensitivities to bitter compounds, but the intercorrelation of these sensitivities is unknown. Our goal was to investigate correlations as a function of individual sensitivities to several bitter compounds representative of different chemical classes and, from these correlations, infer the number and variety of potential bitterness transduction systems for these compounds. Twenty-six subjects rated and ranked quinine HCl, caffeine, (-)-epicatechin, tetralone, L-phenylalanine, L-tryptophan, magnesium sulfate, urea, sucrose octaacetate (SOA), denatonium benzoate, and n-propylthiouracil (PROP) for bitterness. By examining individual differences, ratings and rankings could be grouped into two general clusters--urea/phenylalanine/tryptophan/epicatechin, and quinine/caffeine/SOA/denatonium benzoate/tetralone/magnesium sulfate-none of which contained PROP. When subjects were grouped into the extremes of sensitivity to PROP, a significant difference was found in the bitterness ratings, but not in the rankings. Therefore, there are also subjects who possess diminished absolute sensitivity to bitter stimuli but do not differ from other subjects in their relative sensitivities to these compounds.
Authors:
J F Delwiche; Z Buletic; P A Breslin
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Perception & psychophysics     Volume:  63     ISSN:  0031-5117     ISO Abbreviation:  Percept Psychophys     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-08-27     Completed Date:  2001-09-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0200445     Medline TA:  Percept Psychophys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  761-76     Citation Subset:  IM    
Affiliation:
Ohio State University, Columbus, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Female
Humans
Individuality*
Male
Propylthiouracil
Reference Standards
Reference Values
Taste Buds / physiology*
Taste Threshold / physiology*
Grant Support
ID/Acronym/Agency:
F32 DC00384-02/DC/NIDCD NIH HHS; R29 DC02995/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
51-52-5/Propylthiouracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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