Document Detail

Covariation of corticospinal efficiency and silent period in motoneuron diseases.
MedLine Citation:
PMID:  16691593     Owner:  NLM     Status:  MEDLINE    
For a better understanding of the changes affecting the cortically induced silent period (SP) in motoneuron disease, the excitatory and inhibitory effects of transcranial magnetic stimulation were explored repeatedly in 8 patients with amyotrophic lateral sclerosis (ALS), 3 patients with Kennedy's disease (KD), and 10 healthy subjects. In KD, the background electromyogram (EMG) and the motor evoked potential (MEP) area were both enhanced. However, neither the corticospinal efficiency (MEP gain, the ratio between MEP and background EMG) nor the duration of the SP differed from healthy subjects. In ALS patients, the MEP gain and the SP duration decreased conspicuously with time. We conclude that use of the MEP gain improves detection of corticospinal dysfunction in ALS patients. Part of the SP shortening in ALS seems to reflect the reduced activation of cortical or spinal inhibitory networks by the abnormal corticospinal pathway.
S Attarian; J Pouget; A Schmied
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Muscle & nerve     Volume:  34     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-21     Completed Date:  2006-09-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  178-88     Citation Subset:  IM    
Department of Neurology and Neuromuscular Diseases, CHU La Timone, 264 rue Saint-Pierre, 13385 Marseille, France.
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MeSH Terms
Amyotrophic Lateral Sclerosis / physiopathology
Data Interpretation, Statistical
Electric Stimulation
Evoked Potentials, Motor / physiology
Follow-Up Studies
Longitudinal Studies
Middle Aged
Motor Neuron Disease / physiopathology*
Muscle Contraction / physiology
Muscle, Skeletal / physiopathology
Muscular Atrophy, Spinal / physiopathology
Prospective Studies
Pyramidal Tracts / physiopathology*

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