Document Detail


Covalent immobilization of invertase and horseradish peroxidase on concanavalin A-Seralose via carbohydrate moieties.
MedLine Citation:
PMID:  7549967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Invertase from Baker's yeast (Saccharomyces cerevisiae) and Horseradish peroxidase (HRP) were covalently immobilized on Concanavalin A precoupled to Seralose via carbohydrate moieties. Covalent coupling of glycoenzymes was achieved by periodate induced aldehydic groups of glycosyls with amino groups of Concanavalin A, at different pH values. A bifunctional reagent such as glutaraldehyde crosslinks the glycoenzymes with lectin both intra and intermolecularly. Therefore, attempts were made to introduce covalent linkages between glycoenzymes and Concanavalin A-Seralose without intramolecular crosslinking in either. The immobilized preparations of glycoenzymes exhibited high yield of immobilization and eta value. About 90 and 85% covalent coupling could be observed in invertase and HRP at pH 7.0 respectively, as determined by treatment with 0.5 M methyl alpha-D-mannopyranoside. All immobilized glycoenzyme preparations exhibited marked stabilization towards thermal inactivation.
Authors:
S Husain; F Jafri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemistry and molecular biology international     Volume:  36     ISSN:  1039-9712     ISO Abbreviation:  Biochem. Mol. Biol. Int.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-11-22     Completed Date:  1995-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9306673     Medline TA:  Biochem Mol Biol Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  669-77     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, India.
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MeSH Terms
Descriptor/Qualifier:
Carbohydrates
Concanavalin A
Enzymes, Immobilized*
Glycoside Hydrolases*
Hydrogen-Ion Concentration
Peroxidase*
Plant Lectins
Plants / enzymology
Saccharomyces cerevisiae / enzymology
beta-Fructofuranosidase
Chemical
Reg. No./Substance:
0/Carbohydrates; 0/Enzymes, Immobilized; 0/Plant Lectins; 11028-71-0/Concanavalin A; EC 1.11.1.7/Peroxidase; EC 3.2.1.-/Glycoside Hydrolases; EC 3.2.1.26/beta-Fructofuranosidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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