| Covalent biofunctionalization of silicon nitride surfaces. | |
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MedLine Citation:
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PMID: 17455968 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Covalently attached organic monolayers on etched silicon nitride (SixN4; x >/= 3) surfaces were prepared by reaction of SixN4-coated wafers with neat or solutions of 1-alkenes and 1-alkynes in refluxing mesitylene. The surface modification was monitored by measurement of the static water contact angle, XPS, IRRAS, AFM, and ToF-SIMS, and evidence for the formation of Si-C bonds is presented. The etching can be achieved by dilute HF solutions and yields both Si-H and N-H moieties. The resulting etched SixN4 surfaces are functionalized by terminal carboxylic acid groups in either of two ways: (a) via attachment of a 10-undecenoic acid 2,2,2-trifluoroethyl ester (trifluoro ethanol ester) and subsequent thermal acid hydrolysis; (b) through attachment of a photocleavable ester, and subsequent photochemical cleavage, as this would allow photopatterned functionalized SixN4. The carboxylic acids are successfully used for the attachment of oligopeptides (aspartame) and complete proteins using EDC/NHS chemistry. Finally, an amino-terminated organic monolayer can be formed by reaction of HF-treated SixN4 surfaces with a N-(omega-undecylenyl)phthalimide, which yields an amino-terminated surface upon deprotection with hydrazine. |
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Authors:
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Ahmed Arafat; Marcel Giesbers; Michel Rosso; Ernst J R Sudhölter; Karin Schroën; Richard G White; Li Yang; Matthew R Linford; Han Zuilhof |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-04-25 |
Journal Detail:
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Title: Langmuir : the ACS journal of surfaces and colloids Volume: 23 ISSN: 0743-7463 ISO Abbreviation: Langmuir Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-05-15 Completed Date: 2007-07-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9882736 Medline TA: Langmuir Country: United States |
Other Details:
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Languages: eng Pagination: 6233-44 Citation Subset: IM |
Affiliation:
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Laboratory of Organic Chemistry, Wageningen University, Dreijenplein 8, 6703 HB Wageningen, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adsorption Animals Biosensing Techniques Cattle Coated Materials, Biocompatible / chemistry Microscopy, Atomic Force Oligopeptides / chemistry Proteins / chemistry Silicon Compounds / chemistry* Spectrometry, Mass, Secondary Ion Spectrum Analysis Surface Properties X-Rays |
| Chemical | |
Reg. No./Substance:
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0/Coated Materials, Biocompatible; 0/Oligopeptides; 0/Proteins; 0/Silicon Compounds; 12033-89-5/silicon nitride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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