| Courting a cure for fragile X. | |
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MedLine Citation:
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PMID: 15748838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fragile X syndrome is the most common heritable cause of mental retardation. Previous work has suggested that overactive signaling by group I metabotropic glutamate receptors (mGluRs) may be a mechanism underlying many of the disease symptoms. As a test of this theory, McBride et al. show that in a Drosophila model for Fragile X syndrome, treatment with mGluR antagonists can rescue short-term memory, courtship, and mushroom body defects. |
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Authors:
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Gül Dölen; Mark F Bear |
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Publication Detail:
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Type: Comment; Journal Article; Review |
Journal Detail:
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Title: Neuron Volume: 45 ISSN: 0896-6273 ISO Abbreviation: Neuron Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-07 Completed Date: 2005-04-12 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8809320 Medline TA: Neuron Country: United States |
Other Details:
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Languages: eng Pagination: 642-4 Citation Subset: IM |
Affiliation:
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Howard Hughes Medical Institute, The Picower Center for Learning and Memory, Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Fragile X Syndrome / drug therapy, metabolism* Humans Receptors, Metabotropic Glutamate / antagonists & inhibitors, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Metabotropic Glutamate |
| Comments/Corrections | |
Comment On:
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Neuron. 2005 Mar 3;45(5):753-64
[PMID:
15748850
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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