Document Detail

Course of psychiatric disorders in pregnancy. Dilemmas in pharmacologic management.
MedLine Citation:
PMID:  7990794     Owner:  NLM     Status:  MEDLINE    
Although it is generally believed that pregnancy is a time of emotional well-being, many women develop or have a recurrence of psychiatric illness during this time. The risks associated with leaving a woman untreated during pregnancy are potentially substantial and must be weighed against the risks of exposing the fetus to the potentially teratogenic medications. Large prospective and retrospective studies suggest a relative safety of use of tricyclic antidepressants during pregnancy. Data available for neuroleptics, lithium, benzodiazepines, and the anticonvulsants valproic acid and carbamazepine, although mixed, point to increased risks of congenital malformations in the children of mothers exposed to these agents in the first trimester of pregnancy. Very little is known about the behavioral abnormalities in offspring of mothers exposed to these agents. Animal studies suggest changes in brain receptor number and function in the offspring of mothers on a variety of psychotropic drugs studied to date. The few human studies do not suggest long term effects, but given the very limited data, no definitive conclusions can be drawn. Large epidemiologic follow-up studies of children exposed to medication in utero may help clarify questions relating to behavioral changes and thus help guide clinical decisions.
L L Altshuler; M P Szuba
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurologic clinics     Volume:  12     ISSN:  0733-8619     ISO Abbreviation:  Neurol Clin     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-01-12     Completed Date:  1995-01-12     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8219232     Medline TA:  Neurol Clin     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  613-35     Citation Subset:  IM    
Department of Psychiatry, University of California, Los Angeles.
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MeSH Terms
Abnormalities, Drug-Induced / etiology*,  prevention & control
Antipsychotic Agents / adverse effects,  therapeutic use
Infant, Newborn
Mental Disorders / drug therapy*,  psychology
Psychotropic Drugs / adverse effects*,  therapeutic use
Puerperal Disorders / drug therapy,  psychology
Risk Factors
Reg. No./Substance:
0/Antipsychotic Agents; 0/Psychotropic Drugs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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