| Course of preeclamptic glomerular injury after delivery. | |
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MedLine Citation:
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PMID: 18199600 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the early postpartum recovery of glomerular function over 4 wk in 57 women with preeclampsia. We used physiological techniques to measure glomerular filtration rate (GFR), renal plasma flow, and oncotic pressure (pi(A)) and computed a value for the two-kidney ultrafiltration coefficient (K(f)). Compared with healthy, postpartum controls, GFR was depressed by 40% on postpartum day 1, but by only 19% and 8% in the second and fourth postpartum weeks, respectively. Hypofiltration was attributable solely to depression, at corresponding postpartum times, of K(f) by 55%, 30%, and 18%, respectively. Improvement in glomerular filtration capacity was accompanied by recovery of hypertension to near-normal levels and significant improvement in albuminuria. We conclude that the functional manifestations of the glomerular endothelial injury of preeclampsia largely resolve within the first postpartum month. |
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Authors:
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M A Hladunewich; B D Myers; G C Derby; K L Blouch; M L Druzin; W M Deen; D M Naimark; R A Lafayette |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-01-16 |
Journal Detail:
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Title: American journal of physiology. Renal physiology Volume: 294 ISSN: 1931-857X ISO Abbreviation: Am. J. Physiol. Renal Physiol. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-28 Completed Date: 2008-05-08 Revised Date: 2011-04-28 |
Medline Journal Info:
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Nlm Unique ID: 100901990 Medline TA: Am J Physiol Renal Physiol Country: United States |
Other Details:
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Languages: eng Pagination: F614-20 Citation Subset: IM |
Affiliation:
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Division of Nephrology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada. michelle.hladunewich@sunnybrook.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cross-Sectional Studies Female Glomerular Filtration Rate / physiology* Humans Kidney Glomerulus / physiopathology* Models, Biological Postpartum Period / physiology Pre-Eclampsia / physiopathology* Pregnancy |
| Grant Support | |
ID/Acronym/Agency:
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DK-52876/DK/NIDDK NIH HHS; M01-RR-00070/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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