| Course of Henoch-Schönlein nephritis after renal transplantation. Report on ten patients and review of the literature. | |
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MedLine Citation:
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PMID: 7992359 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The frequency and the risk factors for clinical recurrence of Henoch-Schönlein nephritis following renal transplantation (TP) remain largely unknown. We report on 14 transplants performed at our center in 10 patients, detail the evolution of 2 of them with clinical recurrence, and review 64 other transplants reported in the literature. In our series, all patients are currently alive. Seven grafts are well-functioning 22-295 (mean, 97) months after TP without any sign of clinical recurrence. Five grafts were lost from rejection. Clinical recurrence occurred in 2 patients who were on cyclosporine/azathioprine/prednisone therapy. Pooling our series with that of Hasegawa et al., the actuarial risk for renal recurrence and for graft loss due to recurrence was 35 and 11% at 5 years after TP, respectively. In our series, duration of original disease was 2 and 28 months in the 2 patients with recurrence versus 31-144 months in the others without recurrence. In the literature, this duration was < or = 36 months in all 7 patients with recurrence. Recurrence occurred despite a > 12-month delay between disappearance of purpura and TP in our 2 patients and in 3 of 6 previously reported recurrences. We conclude that Henoch-Schönlein purpura nephritis frequently recurs after TP. Recurrence (1) seems to be associated with a shorter duration of the original disease, (2) can occur despite a delay of more than 1 year (as commonly advised) between disappearance of purpura and TP, and (3) is not prevented by a triple immunosuppressive regimen that includes cyclosporine. |
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Authors:
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Q Meulders; Y Pirson; J P Cosyns; J P Squifflet; C van Ypersele de Strihou |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Transplantation Volume: 58 ISSN: 0041-1337 ISO Abbreviation: Transplantation Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1995-01-06 Completed Date: 1995-01-06 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0132144 Medline TA: Transplantation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1179-86 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Cliniques Universitaires St. Luc, Brussels, Belgium. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Child, Preschool Female Humans Kidney Transplantation / adverse effects* Male Middle Aged Nephritis / complications, epidemiology, etiology*, surgery Purpura, Schoenlein-Henoch / complications, epidemiology, etiology*, surgery Risk Factors Survival Analysis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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