Document Detail

Cournand lecture. Expiratory partial pressure curves in the diagnosis of emphysema.
MedLine Citation:
PMID:  3011156     Owner:  NLM     Status:  MEDLINE    
The deformation of expiratory partial pressure curves of respiratory and inert gases (O2, CO2, He, Ar, SF6), as measured by means of mass spectrometry, was analysed in healthy subjects and in patients with asthma, chronic bronchitis and/or pulmonary emphysema. Patients with emphysema could best be distinguished from the other groups when the comparison was based on the shape of expirogram phase II. Phase II was characterized by the volume V25-50 which was expired between 25% and 50% of the inspiratory/end-tidal partial pressure difference. Comparative measurements of V25-50 of O2, CO2, He and SF6 in 10 healthy subjects (mean age: 30.8 yr) and in 10 patients with advanced emphysema (mean age: 60.8 yr) showed a linear increase of V25-50 with increasing inspired volume (VI) being 3-5 times higher in the patients than in normals. V25-50 increased with the sequence He less than SF6 approximately equal to CO2 less than O2 in both groups. The separation between phase II volumes of He and SF6 was more pronounced in the patients with emphysema than in the healthy subjects. Variations of the breathing pattern in eight healthy subjects revealed a linear increase of V25-50 with increasing VI and, to a lower extent, with increasing respiratory frequency, while a decrease of V25-50 with increasing breath-holding time and only very small changes with variations of inspiratory as well as expiratory duration were observed.(ABSTRACT TRUNCATED AT 250 WORDS)
H Worth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin européen de physiopathologie respiratoire     Volume:  22     ISSN:  0395-3890     ISO Abbreviation:  Bull Eur Physiopathol Respir     Publication Date:    1986 Mar-Apr
Date Detail:
Created Date:  1986-06-27     Completed Date:  1986-06-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7605263     Medline TA:  Bull Eur Physiopathol Respir     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  191-9     Citation Subset:  IM    
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MeSH Terms
Acetylcholine / diagnostic use
Airway Resistance / drug effects
Bronchitis / diagnosis
Carbon Dioxide / diagnostic use
Fenoterol / diagnostic use
Lung Volume Measurements
Middle Aged
Noble Gases / diagnostic use
Oxygen / diagnostic use
Pulmonary Emphysema / diagnosis*
Respiratory Function Tests / methods
Reg. No./Substance:
0/Noble Gases; 124-38-9/Carbon Dioxide; 13392-18-2/Fenoterol; 51-84-3/Acetylcholine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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