| Coupling desorption electrospray ionisation and neutral desorption/extractive electrospray ionisation with a travelling-wave based ion mobility mass spectrometer for the analysis of drugs. | |
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MedLine Citation:
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PMID: 18069748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Desorption electrospray ionisation (DESI) and neutral desorption/extractive electrospray ionisation (EESI) have been coupled to a hybrid quadrupole travelling-wave (T-Wave)-based ion mobility time-of-flight mass spectrometer for the direct accurate mass analysis of active ingredients formulated into pharmaceutical samples. The collision cross-section measurements of polyethylene glycol (PEG) excipients detected in one formulation were estimated and compared with published data. These estimated collision cross-sections of the PEG species showed good agreement with published data. |
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Authors:
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Jonathan P Williams; James H Scrivens |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Rapid communications in mass spectrometry : RCM Volume: 22 ISSN: 0951-4198 ISO Abbreviation: Rapid Commun. Mass Spectrom. Publication Date: 2008 |
Date Detail:
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Created Date: 2007-12-25 Completed Date: 2008-04-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8802365 Medline TA: Rapid Commun Mass Spectrom Country: England |
Other Details:
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Languages: eng Pagination: 187-96 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2007 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry, UK. j.p.williams@warwick.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetaminophen
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analysis Analgesics / analysis Anti-Infective Agents, Local / analysis Benzocaine / analysis Caffeine / analysis Chlorhexidine / analogs & derivatives, analysis Codeine / analogs & derivatives, analysis Dentifrices / analysis Drug Combinations Gels / analysis Pharmaceutical Preparations / analysis* Polyethylene Glycols / analysis Spectrometry, Mass, Electrospray Ionization / methods* Tandem Mass Spectrometry / methods* |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Anti-Infective Agents, Local; 0/Dentifrices; 0/Drug Combinations; 0/Gels; 0/Pharmaceutical Preparations; 0/Polyethylene Glycols; 103-90-2/Acetaminophen; 18472-51-0/chlorhexidine gluconate; 55-56-1/Chlorhexidine; 58-08-2/Caffeine; 76-57-3/Codeine; 82400-20-2/solpadeine; 94-09-7/Benzocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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