Document Detail


Coupling desorption electrospray ionisation and neutral desorption/extractive electrospray ionisation with a travelling-wave based ion mobility mass spectrometer for the analysis of drugs.
MedLine Citation:
PMID:  18069748     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Desorption electrospray ionisation (DESI) and neutral desorption/extractive electrospray ionisation (EESI) have been coupled to a hybrid quadrupole travelling-wave (T-Wave)-based ion mobility time-of-flight mass spectrometer for the direct accurate mass analysis of active ingredients formulated into pharmaceutical samples. The collision cross-section measurements of polyethylene glycol (PEG) excipients detected in one formulation were estimated and compared with published data. These estimated collision cross-sections of the PEG species showed good agreement with published data.
Authors:
Jonathan P Williams; James H Scrivens
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Rapid communications in mass spectrometry : RCM     Volume:  22     ISSN:  0951-4198     ISO Abbreviation:  Rapid Commun. Mass Spectrom.     Publication Date:  2008  
Date Detail:
Created Date:  2007-12-25     Completed Date:  2008-04-01     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8802365     Medline TA:  Rapid Commun Mass Spectrom     Country:  England    
Other Details:
Languages:  eng     Pagination:  187-96     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2007 John Wiley & Sons, Ltd.
Affiliation:
Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry, UK. j.p.williams@warwick.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / analysis
Analgesics / analysis
Anti-Infective Agents, Local / analysis
Benzocaine / analysis
Caffeine / analysis
Chlorhexidine / analogs & derivatives,  analysis
Codeine / analogs & derivatives,  analysis
Dentifrices / analysis
Drug Combinations
Gels / analysis
Pharmaceutical Preparations / analysis*
Polyethylene Glycols / analysis
Spectrometry, Mass, Electrospray Ionization / methods*
Tandem Mass Spectrometry / methods*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Analgesics; 0/Anti-Infective Agents, Local; 0/Dentifrices; 0/Drug Combinations; 0/Gels; 0/Pharmaceutical Preparations; 0/Polyethylene Glycols; 103-90-2/Acetaminophen; 55-56-1/Chlorhexidine; 58-08-2/Caffeine; 76-57-3/Codeine; 82400-20-2/solpadeine; 94-09-7/Benzocaine; MOR84MUD8E/chlorhexidine gluconate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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