| Coupling between the blood lactate-to-pyruvate ratio and MCA Vmean at the onset of exercise in humans. | |
| | |
MedLine Citation:
|
PMID: 19779155 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Activation-induced increase in cerebral blood flow is coupled to enhanced metabolic activity, maybe with brain tissue redox state and oxygen tension as key modulators. To evaluate this hypothesis at the onset of exercise in humans, blood was sampled at 0.1 to 0.2 Hz from the radial artery and right internal jugular vein, while middle cerebral artery mean flow velocity (MCA V(mean)) was recorded. Both the arterial and venous lactate-to-pyruvate ratio increased after 10 s (P < 0.05), and the arterial ratio remained slightly higher than the venous (P < 0.05). The calculated average cerebral capillary oxygen tension decreased by 2.7 mmHg after 5 s (P < 0.05), while MCA V(mean) increased only after 30 s. Furthermore, there was an unaccounted cerebral carbohydrate uptake relative to the uptake of oxygen that became significant 50 s after the onset of exercise. These findings support brain tissue redox state and oxygenation as potential modulators of an increase in cerebral blood flow at the onset of exercise. |
| | |
Authors:
|
Peter Rasmussen; Camilla A Madsen; Henning B Nielsen; Morten Zaar; Albert Gjedde; Niels H Secher; Bj??rn Quistorff |
Related Documents
:
|
12604575 - Diving experience and the aerobic dive capacity of muskrats: does training produce a be... 711815 - The effect of furosemide on renal function in open heart surgery. 8210755 - Blood gases, ph and hematology of montane and lowland coot embryos. 2113805 - Preservation of single-flash visual evoked potentials at very low cerebral oxygen deliv... 15001135 - Volume expansion during neonatal intensive care: do we know what we are doing? 7137385 - Role of central and peripheral chemoreceptors in diving responses of ducks. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-24 |
Journal Detail:
|
Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 107 ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-12-02 Completed Date: 2010-02-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: 1799-805 Citation Subset: IM |
Affiliation:
|
1Department of Anesthesia, Copenhagen Muscle Research Center, Rigshospitalet, Copenhagen, Denmark. peter@prec.dk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Blood Flow Velocity / physiology* Blood Pressure / physiology Catheters, Indwelling Cerebrovascular Circulation / physiology Exercise / physiology* Heart Rate / physiology Humans Lactic Acid / blood* Male Middle Cerebral Artery / physiology*, ultrasonography Models, Biological Oxygen Consumption / physiology Pyruvic Acid / blood* Signal Processing, Computer-Assisted Time Factors Ultrasonography, Doppler, Transcranial |
| Chemical | |
Reg. No./Substance:
|
127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Doxorubicin acts through tumor necrosis factor receptor subtype 1 to cause dysfunction of murine ske...
Next Document: Impaired overload-induced hypertrophy in Obese Zucker rat slow-twitch skeletal muscle.