| Coupling active hair bundle mechanics, fast adaptation, and somatic motility in a cochlear model. | |
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MedLine Citation:
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PMID: 21641302 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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One of the central questions in the biophysics of the mammalian cochlea is determining the contributions of the two active processes, prestin-based somatic motility and hair bundle (HB) motility, to cochlear amplification. HB force generation is linked to fast adaptation of the transduction current via a calcium-dependent process and somatic force generation is driven by the depolarization caused by the transduction current. In this article, we construct a global mechanical-electrical-acoustical mathematical model of the cochlea based on a three-dimensional fluid representation. The global cochlear model is coupled to linearizations of nonlinear somatic motility and HB activity as well as to the micromechanics of the passive structural and electrical elements of the cochlea. We find that the active HB force alone is not sufficient to power high frequency cochlear amplification. However, somatic motility can overcome resistor-capacitor filtering by the basolateral membrane and deliver sufficient mechanical energy for amplification at basal locations. The results suggest a new theory for high frequency active cochlear mechanics, in which fast adaptation controls the transduction channel sensitivity and thereby the magnitude of the energy delivered by somatic motility. |
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Authors:
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Julien Meaud; Karl Grosh |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biophysical journal Volume: 100 ISSN: 1542-0086 ISO Abbreviation: Biophys. J. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370626 Medline TA: Biophys J Country: United States |
Other Details:
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Languages: eng Pagination: 2576-85 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Biophysical Society. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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