| Coupling of apoptosis and L/R patterning controls stepwise organ looping. | |
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MedLine Citation:
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PMID: 20832313 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Handed asymmetry in organ shape and positioning is a common feature among bilateria, yet little is known about the morphogenetic mechanisms underlying left-right (LR) organogenesis. We utilize the directional 360° clockwise rotation of genitalia in Drosophila to study LR-dependent organ looping. Using time-lapse imaging, we show that rotation of genitalia by 360° results from an additive process involving two ring-shaped domains, each undergoing 180° rotation. Our results show that the direction of rotation for each ring is autonomous and strictly depends on the LR determinant myosin ID (MyoID). Specific inactivation of MyoID in one domain causes rings to rotate in opposite directions and thereby cancels out the overall movement. We further reveal a specific pattern of apoptosis at the ring boundaries and show that local cell death is required for the movement of each domain, acting as a brake-releaser. These data indicate that organ looping can proceed through an incremental mechanism coupling LR determination and apoptosis. Furthermore, they suggest a model for the stepwise evolution of genitalia posture in Diptera, through the emergence and duplication of a 180° LR module. |
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Authors:
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Magali Suzanne; Astrid G Petzoldt; Pauline Spéder; Jean-Baptiste Coutelis; Hermann Steller; Stéphane Noselli |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-09-09 |
Journal Detail:
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Title: Current biology : CB Volume: 20 ISSN: 1879-0445 ISO Abbreviation: Curr. Biol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-12 Completed Date: 2011-01-31 Revised Date: 2011-12-05 |
Medline Journal Info:
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Nlm Unique ID: 9107782 Medline TA: Curr Biol Country: England |
Other Details:
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Languages: eng Pagination: 1773-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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University of Nice Sophia-Antipolis, CNRS, Institute of Developmental Biology and Cancer, Parc Valrose, 06108 Nice Cedex 2, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / physiology* Body Patterning / physiology* Drosophila melanogaster* / anatomy & histology, embryology, growth & development Genitalia / anatomy & histology, embryology, growth & development Organogenesis / physiology* Time-Lapse Imaging |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM060124-13/GM/NIGMS NIH HHS; R01 GM60124/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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