Document Detail


Couples dropping out of a reimbursed intrauterine insemination program: what is their prognostic profile and why do they drop out?
MedLine Citation:
PMID:  23312227     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate whether baseline characteristics and prognostic profiles differed between couples who drop out from intrauterine insemination (IUI) and couples that continue IUI, and the reasons for couples dropping out from IUI programs. DESIGN: Retrospective observational cohort study. SETTING: Fertility centers. PATIENT(S): Consecutive subfertile couples undergoing IUI. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Characteristics and prognosis of ongoing pregnancy after IUI at the start of treatment of couples that dropped out compared with couples that continued treatment or achieved an ongoing pregnancy. RESULT(S): We studied 803 couples who underwent 3,579 IUI cycles of whom 221 couples dropped out (28%). Couples dropping out completed 2.8 (SD ±1.4) cycles per couple compared with 4.5 (SD ±2.3) cycles per couple for those continuing treatment. Couples dropping out had a higher female age, longer subfertility duration, and higher basal FSH. Mean prognosis to achieve an ongoing pregnancy after IUI at start of treatment was 7.9% (SD ±2.4) per cycle for couples who dropped out and 8.5% (SD ±2.5) per cycle for couples continuing treatment. Of the dropouts, 100 couples (45%) were actively censored from the IUI program, 87 couples (39%) because of poor prognosis; 121 couples (55%) were passively censored from the program, of whom 62 (28%) dropped out owing to personal reasons; 59 couples (27%) were lost to follow-up. CONCLUSION(S): We found significant differences in prognostic profile between couples continuing treatment and couples dropping out, although these differences seem limited from a clinical perspective. We conclude that overestimation of ongoing pregnancy rates after IUI due to couples dropping out is limited.
Authors:
Inge M Custers; Thierry H J H M van Dessel; Paul A Flierman; Pieternel Steures; Madelon van Wely; Fulco van der Veen; Ben W J Mol
Related Documents :
17304417 - Preeclampsia and brain damage among preterm infants: a changed panorama in a 20-year an...
17207337 - Air fluid versus fluid-only models of embryo catheter loading: a systematic review and ...
19426177 - Change in periodontitis during pregnancy and the risk of pre-term birth and low birthwe...
18367737 - Cervical length at mid-pregnancy and the risk of primary cesarean delivery.
16616027 - Recurrence rates of arrhythmias during pregnancy in women with previous tachyarrhythmia...
1157967 - The effect of a copper intrauterine device during the early stages of pregnancy in the ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-8
Journal Detail:
Title:  Fertility and sterility     Volume:  -     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Affiliation:
Centre for Reproductive Medicine, Academic Medical Center, Amsterdam, the Netherlands. Electronic address: i.m.custers@amc.uva.nl.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cardiometabolic health of children conceived by assisted reproductive technologies.
Next Document:  Profiling the gene signature of endometrial receptivity: clinical results.