Document Detail


Coupled motions in enzyme catalysis.
MedLine Citation:
PMID:  20729130     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recently, the hypothesis that protein motions are involved in enzymatic turnover has gained significant attention. We review cases where there is evidence that protein motions are rate-limiting in the overall catalytic cycle and examine experimental and theoretical evidence for how such motions enhance the probability of sampling the transition state configurations relative to the ground state. The impact of tunneling, the possible role of vibrational coupling and the value of conformational chemical landscapes are also scrutinized.
Authors:
Vishal C Nashine; Sharon Hammes-Schiffer; Stephen J Benkovic
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-08-20
Journal Detail:
Title:  Current opinion in chemical biology     Volume:  14     ISSN:  1879-0402     ISO Abbreviation:  Curr Opin Chem Biol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-12     Completed Date:  2011-01-19     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  9811312     Medline TA:  Curr Opin Chem Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  644-51     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Chemistry, The Pennsylvania State University, 414 Wartik Laboratory, University Park, PA 16802, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Biocatalysis*
Enzymes / chemistry,  metabolism*
Humans
Kinetics
Magnetic Resonance Spectroscopy
Molecular Dynamics Simulation
Movement*
Grant Support
ID/Acronym/Agency:
1R01GM092946/GM/NIGMS NIH HHS; GM56207/GM/NIGMS NIH HHS; R01 GM056207-12/GM/NIGMS NIH HHS; R01 GM092946/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Enzymes
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Vitamins in plants: occurrence, biosynthesis and antioxidant function.
Next Document:  Oral metastatic hepatocellular carcinoma: a changing demographic in Europe and North America. Immuno...