Document Detail

Counting small hypointense spots confounds the quantification of functional islet mass based on islet MRI.
MedLine Citation:
PMID:  22299723     Owner:  NLM     Status:  MEDLINE    
Iron-containing fragmented islets or free iron released from dying cells could confound the interpretation of MRI of iron nanoparticle-labeled islets. Exclusion of small hypointense spots could be a useful strategy to avoid such artifact. We investigated whether this strategy could improve the estimation of functioning islet mass after islet transplantation. Using a rat syngeneic intraportal islet transplantation model, we quantitatively assessed the relationships between total area, number of hypointense spots on MRI that belong to each size quartile and glycemic control of the recipients. The total area of hypointense spots on MRI was greater in the recipients that achieved diabetes reversal (p = 0.002), whereas the total number of hypointense spots was not different (p = 0.757). Exclusion of small hypointense spots improved the association between the number of hypointense spots and the blood glucose level of the recipients (p < 0.001). Ex-vivo imaging and histologic study confirmed that some small hypointense spots represent the phagocytosed free iron. Exclusion of small hypointense spots improved the quantification of the functional islet mass based on islet MRI. This would be a useful principle in the development of an algorithm to estimate functioning islet mass based on islet MRI.
J H Kim; S M Jin; S H Oh; S Lee; B J Oh; S K Kim; S Suh; J H Lee; H S Jung; M-S Lee; M-K Lee; K-W Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-02
Journal Detail:
Title:  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons     Volume:  12     ISSN:  1600-6143     ISO Abbreviation:  Am. J. Transplant.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-27     Completed Date:  2012-08-28     Revised Date:  2013-04-11    
Medline Journal Info:
Nlm Unique ID:  100968638     Medline TA:  Am J Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1303-12     Citation Subset:  IM    
Copyright Information:
© Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons.
Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
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MeSH Terms
Blood Glucose / metabolism
Contrast Media / diagnostic use
Dextrans / diagnostic use*
Diabetes Mellitus, Experimental / pathology*,  surgery*
Graft Rejection / diagnosis,  etiology
Islets of Langerhans / pathology*
Islets of Langerhans Transplantation*
Magnetic Resonance Imaging*
Magnetite Nanoparticles / diagnostic use*
Rats, Inbred Lew
Rats, Wistar
Reg. No./Substance:
0/Blood Glucose; 0/Contrast Media; 0/Magnetite Nanoparticles; 9004-54-0/Dextrans; G6N3J05W84/ferumoxides

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