| Counterregulatory hormonal responses to hypoglycaemia in type 1 (insulin-dependent) diabetes: evidence for diminished hypothalamic-pituitary hormonal secretion. | |
| | |
MedLine Citation:
|
PMID: 2851469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Acute insulin-induced hypoglycaemia in humans provokes autonomic neural activation and counterregulatory hormonal secretion mediated in part via hypothalamic stimulation. Many patients with Type 1 (insulin-dependent) diabetes have acquired deficiencies of counterregulatory hormonal release following hypoglycaemia. To study the integrity of the hypothalamic-pituitary and the sympatho-adrenal systems, the responses of pituitary hormones, beta-endorphin, glucagon and adrenaline to acute insulin-induced hypoglycaemia (0.2 units/kg) were examined in 16 patients with Type 1 diabetes who did not have autonomic neuropathy. To examine the effect of duration of diabetes these patients were subdivided into two groups (Group 1: 8 patients less than 5 years duration; Group 2: 8 patients greater than 15 years duration) and were compared with 8 normal volunteers (Group 3). The severity and time of onset of hypoglycaemia were similar in all 3 groups, but mean blood glucose recovery was slower in the diabetic groups (p less than 0.01). The mean responses of glucagon, adrenaline, adrenocorticotrophic hormone, prolactin and beta-endorphin were similar in all 3 groups, but the mean responses of growth hormone were lower in both diabetic groups than in the normal group (p less than 0.05). The mean increments of glucagon and adrenaline in the diabetic groups were lower than the normal group, but these differences did not achieve significance; glucagon secretion was preserved in several diabetic patients irrespective of duration of disease. Various hormonal responses to hypoglycaemia were absent or diminished in individual diabetic patients, and multiple hormonal deficiencies could be implicated in delaying blood glucose recovery.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
B M Frier; B M Fisher; C E Gray; G H Beastall |
Related Documents
:
|
20609969 - Once weekly exenatide compared with insulin glargine titrated to target in patients wit... 17096709 - Unrecognised hypoglycaemia in children and adolescents with type 1 diabetes using the c... 3280369 - The adjustment of diet and insulin dose during long-term endurance exercise in type 1 (... 8913409 - Insulin lispro: its role in the treatment of diabetes mellitus. 23630429 - An observational study of acarbose treatment in patients with type 2 diabetes from the ... 767189 - Effects of intermittent hypoglycaemia in pregnant rats on the functional development of... 18505189 - Effects of peroral insulin and glucose on circulating insulin-like growth factor-1, its... 23153979 - Endothelial nitric oxide synthase glu298asp (g894t) gene polymorphism in coronary arter... 21628999 - Differential regulation and localization of carboxypeptidase d and carboxypeptidase e i... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Diabetologia Volume: 31 ISSN: 0012-186X ISO Abbreviation: Diabetologia Publication Date: 1988 Jul |
Date Detail:
|
Created Date: 1989-03-23 Completed Date: 1989-03-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0006777 Medline TA: Diabetologia Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 421-9 Citation Subset: IM |
Affiliation:
|
Diabetic Department, Western Infirmary, Glasgow, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenocorticotropic Hormone
/
secretion* Adult Aged Blood Glucose / metabolism Diabetes Mellitus, Type 1 / blood, physiopathology* Epinephrine / secretion Female Glucagon / secretion Growth Hormone / secretion Hormones / blood, secretion* Humans Hypoglycemia / physiopathology* Hypothalamo-Hypophyseal System / physiology, physiopathology* Insulin / diagnostic use Male Middle Aged Prolactin / secretion* Reference Values beta-Endorphin / secretion |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/Hormones; 11061-68-0/Insulin; 51-43-4/Epinephrine; 60617-12-1/beta-Endorphin; 9002-60-2/Adrenocorticotropic Hormone; 9002-62-4/Prolactin; 9002-72-6/Growth Hormone; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Interaction of malnutrition and difluoromethylornithine-induced intestinal mucosal damage: degree of...
Next Document: Time-dependent potentiation of insulin release induced by alpha-ketoisocaproate and leucine in rats:...