| Countermeasure for space flight effects on immune system: nutritional nucleotides. | |
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MedLine Citation:
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PMID: 16044627 Owner: NASA Status: MEDLINE |
Abstract/OtherAbstract:
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Microgravity and its environment have adverse effects on the immune system. Abnormal immune responses observed in microgravity may pose serious consequences, especially for the recent directions of NASA for long-term space missions to Moon, Mars and deep Space exploration. The study of space flight immunology is limited due to relative inaccessibility, difficulty of performing experiments in space, and inadequate provisions in this area in the United States and Russian space programs (Taylor 1993). Microgravity and stress experienced during space flights results in immune system aberration (Taylor 1993). In ground-based mouse models for some of the microgravity effects on the human body, hindlimb unloading (HU) has been reported to cause abnormal cell proliferation and cytokine production (Armstrong et al., 1993, Chapes et al. 1993). In this report, we document that a nutritional nucleotide supplementation as studied in ground-based microgravity analogs, has potential to serve as a countermeasure for the immune dysfunction observed in space travel. |
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Authors:
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A D Kulkarni; K Yamauchi; A Sundaresan; G T Ramesh; N R Pellis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology Volume: 18 ISSN: 1089-988X ISO Abbreviation: Gravit Space Biol Bull Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-07-26 Completed Date: 2005-10-21 Revised Date: 2009-04-08 |
Medline Journal Info:
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Nlm Unique ID: 9816128 Medline TA: Gravit Space Biol Bull Country: United States |
Other Details:
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Languages: eng Pagination: 101-2 Citation Subset: S |
Affiliation:
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Department of Surgery, Medical School and GSBS, Univ. of Texas Health Science Center, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Cytokines / biosynthesis Female Food, Formulated Hindlimb Suspension Immunity / drug effects* Lymphocyte Activation / drug effects Mice Mice, Inbred BALB C RNA / administration & dosage* Rotation Spleen / drug effects*, immunology Uracil / administration & dosage* Weightlessness Countermeasures* Weightlessness Simulation |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 63231-63-0/RNA; 66-22-8/Uracil |
| Investigator | |
Investigator/Affiliation:
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A D Kulkarni / U TX Health Sci Ctr, Houston; N R Pellis / NASA JSC |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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