Document Detail

Countermeasure for space flight effects on immune system: nutritional nucleotides.
MedLine Citation:
PMID:  16044627     Owner:  NASA     Status:  MEDLINE    
Microgravity and its environment have adverse effects on the immune system. Abnormal immune responses observed in microgravity may pose serious consequences, especially for the recent directions of NASA for long-term space missions to Moon, Mars and deep Space exploration. The study of space flight immunology is limited due to relative inaccessibility, difficulty of performing experiments in space, and inadequate provisions in this area in the United States and Russian space programs (Taylor 1993). Microgravity and stress experienced during space flights results in immune system aberration (Taylor 1993). In ground-based mouse models for some of the microgravity effects on the human body, hindlimb unloading (HU) has been reported to cause abnormal cell proliferation and cytokine production (Armstrong et al., 1993, Chapes et al. 1993). In this report, we document that a nutritional nucleotide supplementation as studied in ground-based microgravity analogs, has potential to serve as a countermeasure for the immune dysfunction observed in space travel.
A D Kulkarni; K Yamauchi; A Sundaresan; G T Ramesh; N R Pellis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology     Volume:  18     ISSN:  1089-988X     ISO Abbreviation:  Gravit Space Biol Bull     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-07-26     Completed Date:  2005-10-21     Revised Date:  2009-04-08    
Medline Journal Info:
Nlm Unique ID:  9816128     Medline TA:  Gravit Space Biol Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  101-2     Citation Subset:  S    
Department of Surgery, Medical School and GSBS, Univ. of Texas Health Science Center, USA.
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MeSH Terms
Cells, Cultured
Cytokines / biosynthesis
Food, Formulated
Hindlimb Suspension
Immunity / drug effects*
Lymphocyte Activation / drug effects
Mice, Inbred BALB C
RNA / administration & dosage*
Spleen / drug effects*,  immunology
Uracil / administration & dosage*
Weightlessness Countermeasures*
Weightlessness Simulation
Reg. No./Substance:
0/Cytokines; 63231-63-0/RNA; 66-22-8/Uracil
A D Kulkarni / U TX Health Sci Ctr, Houston; N R Pellis / NASA JSC

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