|Counselling, Case Management and Health Promotion for People Living with HIV/AIDS: An Overview of Systematic Reviews.|
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|PMID: 22961581 Owner: NLM Status: Publisher|
|Our objective was to identify all existing systematic reviews related to counselling, case management and health promotion for people living with HIV/AIDS. For the reviews identified, we assessed the quality and local applicability to support evidence-informed policy and practice. We searched 12 electronic databases and two reviewers independently assessed the 5,398 references retrieved from our searches and included 18 systematic reviews. Each review was categorized according to the topic(s) addressed, quality appraised and summarized by extracting key messages, the year searches were last completed and the countries in which included studies were conducted. Twelve reviews address topics related to counselling and case management (mean quality score of 6.5/11). Eight reviews (mean quality score of 6/11) address topics related to health promotion (two address both domains). The findings from this overview of systematic reviews provide a useful resource for supporting the development and delivery of evidence-informed support services in community settings.|
|Michael G Wilson; Winston Husbands; Lydia Makoroka; Sergio Rueda; Nicole R Greenspan; Angela Eady; Le-Ann Dolan; Rick Kennedy; Jessica Cattaneo; Sean Rourke|
|Type: JOURNAL ARTICLE Date: 2012-9-9|
|Title: AIDS and behavior Volume: - ISSN: 1573-3254 ISO Abbreviation: AIDS Behav Publication Date: 2012 Sep|
|Created Date: 2012-9-10 Completed Date: - Revised Date: -|
Medline Journal Info:
|Nlm Unique ID: 9712133 Medline TA: AIDS Behav Country: -|
|Languages: ENG Pagination: - Citation Subset: -|
|McMaster Health Forum, McMaster University, Hamilton, Canada, email@example.com.|
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Journal ID (nlm-ta): AIDS Behav
Journal ID (iso-abbrev): AIDS Behav
Publisher: Springer US, Boston
© The Author(s) 2012
Electronic publication date: Day: 9 Month: 9 Year: 2012
pmc-release publication date: Day: 9 Month: 9 Year: 2012
Print publication date: Month: 6 Year: 2013
Volume: 17 Issue: 5
First Page: 1612 Last Page: 1625
PubMed Id: 22961581
Publisher Id: 283
|Counselling, Case Management and Health Promotion for People Living with HIV/AIDS: An Overview of Systematic Reviews|
|Michael G. WilsonAff1Aff2Aff3Aff4||
|Nicole R. GreenspanAff6|
McMaster Health Forum, McMaster University, Hamilton, Canada
Centre for Health Economics and Policy Analysis, McMaster University, Hamilton, Canada
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
Ontario HIV Treatment Network, Toronto, Canada
AIDS Committee of Toronto, Toronto, Canada
University of Toronto, Toronto, Canada
Health Research Methodology Programme, McMaster University, Hamilton, Canada
Canadian Working Group on HIV and Rehabilitation, Toronto, Canada
Ontario AIDS Network, Toronto, Canada
Centre for Research on Inner City Health, St. Michael’s Hospital, Toronto, Canada
The cornerstones of community support services for people living with HIV/AIDS (PHAs) are case management, counselling and health promotion. Case management focuses on helping service users to identify their unmet needs, and linking them with the required health and social services to achieve desired outcomes [1–3]. After an initial assessment of needs, the case manager and service user collaborate on a system of referrals, monitoring, follow-up assessment and advocacy to ensure positive outcomes. Needs may vary in scope from those that are considered basic (e.g., food and shelter) to those that may be more remote but instrumental to achieving basic needs (e.g., legal services) . Psycho-social counselling may be an important component of case management but is also a stand-alone intervention. Gerbert et al.  have noted that counselling is one of the most powerful ways to address the psycho-social aspects of HIV, which include managing risky behaviours, coping and social support, depression and treatment adherence . Counselling and case management typically focus on individuals, but health promotion may have a distinctly community focus.
Health promotion is “the combination of educational and environmental supports for actions and conditions of living conducive to health” ; and is a “process of enabling people to take control over, and to improve, their health” . This includes promoting behaviour change to achieve better health, as well as helping people and communities negotiate or dismantle the barriers to good health. Health promotion therefore includes an explicit concern with structural factors that impact health and access to health, which places community engagement and community development as intrinsic components of its mission .
Community-based organizations are integral to delivering these types of support services and programs to help address the increasingly complex health-related and social issues experienced by PHAs [9, 10]. These support services can impact the health of PHAs and those at risk for HIV by helping to prevent future HIV infections and addressing powerful social determinants of health such as increased social support and integration. In addition, offering HIV/AIDS support services through community-based organizations helps ensure that services are attuned to the specific needs of the communities they serve. However, most efforts towards supporting the use of research evidence have focused on clinical and prevention services, with far less effort devoted to mobilizing knowledge about effective practices in community-based organizations that provide essential on-the-ground support for PHAs.
Even though there is some debate about what constitutes “evidence” and the best approaches to effectively translate or transfer evidence to practitioners [11–13], there is general agreement that health practitioners need access to the best available research evidence to inform and support their practice [14–20]. In general, evidence-based practice (or evidence-informed decision-making) refers to practitioners’ use of standards of care whose effectiveness has been demonstrated through research evidence. In other words, decisions about care and treatment should be informed by the best available research evidence. Service providers working within health systems may improve patient, client and service user outcomes. This may then result in more efficient use of health system resources by applying care and treatment options that have been shown to be effective at improving health outcomes.
Systematic reviews are a key source of research evidence for supporting evidence-informed practice at the community level for several reasons. First, using systematic reviews is an efficient use of time for busy managers and service providers because all information on a specific topic has already been identified, selected, appraised, and synthesized in one document . Research users are also less likely to be misled by findings from systematic reviews as compared to other forms of research (e.g., a single experimental study). Also, due to the gains in precision associated with synthesizing multiple studies, systematic reviews may inspire greater confidence in research findings among those who use research to support program and policy development . Lastly, systematic reviews are increasingly incorporating a broader spectrum of research evidence (e.g., syntheses of qualitative evidence) [22–29] to answer questions beyond the standard effectiveness of interventions. This broader range of applications (e.g., issues related to the cost-effectiveness of interventions, and how and why interventions work) increases the relevance of systematic reviews to a wider target audience [21, 30].
To support the delivery of evidence-informed support services in community settings, we conducted an overview of systematic reviews. Our general aim was to mobilize relevant and high-quality research evidence related to counselling, case management and health promotion for PHAs. Our specific objectives were to: (1) identify and assess the quality and local applicability of systematic reviews in each of the two fundamental domains of support services (i.e., counselling and case management, and health promotion); (2) develop user-friendly summaries of the key findings and recommendations from each included systematic review: and (3) broadly disseminate the summaries to community-based organizations that service PHAs.
We searched 12 electronic databases in April 2009 using a search strategy designed to optimize the retrieval of systematic reviews (the search strategy is provided in Appendix A, available as a supplement to the online version of this article). We supplemented this by scanning the reference lists of included systematic reviews. Two teams of reviewers (LM and a research assistant, and LM and WH) independently assessed the titles and abstracts for inclusion. Disagreements were resolved by consensus and a third reviewer (MGW) made a final decision where no consensus could be reached. At this initial stage of reviewing, references were included if they were either a systematic reviews or a primary research study and addressed a topic related to counselling, case management and/or health promotion for people living with HIV/AIDS. Two teams of independent reviewers (LM & WH, and LM & MGW) then assessed the references included after the initial scoping stage to identify the systematic reviews meeting our inclusion criteria.
We retrieved the full-text of all included systematic reviews and two reviewers (WH and LM) conducted a final inclusion assessment. Next, two of us (MGW and SR) conducted independent appraisals of the methodological quality of each included systematic review using the AMSTAR (A MeaSurement Tool to Assess Reviews) instrument . AMSTAR demonstrates both strong face and content validity , and is regarded as an optimal approach for assessing the quality of systematic reviews [32, 33]. This scale produces a quality score between 0 and 11, representing low (scores between 0 and 3), medium (scores between 4 and 7) and high (scores between 8 and 11) quality systematic reviews. We did not assess the quality of the studies included each review, which is typically conducted as part of the reviews themselves. We therefore deemed it more appropriate to provide a gauge to the quality of the methods used by each systematic review to synthesize the primary studies included in them. Using the scores of methodological quality from each review, we calculated average quality scores for each topic domain. We standardized the mean quality score by converting each score into a percentage, which we used to calculate the mean score out of 11. This standardization was necessary due to the fact that the denominators for quality appraisal scores can vary using the AMSTAR tool when a question is deemed to be ‘Not applicable’.
One of us (MGW) then categorized reviews by topic and extracted key messages, the year searches were last completed and the countries in which included studies were conducted (categorized by high and low- and middle-income countries). This work was then checked by three members of the team (WH, SR and LM) for accuracy.
Lastly, we developed user-friendly summaries for each included systematic review. We used an approach developed through a recent study with 31 executive directors and program managers of Canadian community-based organizations from the HIV/AIDS, mental health and addictions and diabetes sectors . The user-friendly summaries are presented in a format that provides: (1) an outline of the topic of the review, a plain language summary and a bulleted list of key messages summary; (2) an outline of the benefits, harms and costs of the intervention, program or service evaluated in the review; and (3) relevant equity and local applicability considerations. All of the user-friendly summaries are available through an HIV/AIDS evidence service (SHARE—Synthesized HIV/AIDS Research Evidence) (http://www.hivevidence.org/SHARE/ResourcesSummaries.aspx) .
Our searches yielded 5,398 references from which we excluded 4,832 based on title and abstract review and 545 after assessing the full-text articles, leaving 18 systematic reviews (12 conducted meta-analyses) that met our inclusion criteria. The study selection process is outlined in Fig. 1.
Twelve of these reviews address topics related to counselling and case management, which have a mean quality score of 6.7/11 (see Table 1). Eight reviews address topics related to health promotion (see Tables 1, 2) which have a mean quality score of 5.9/11. Three address both domains but are presented only in Table 1 (each is identified under footnote a) but are included in the average quality calculations for both domains. Most of the systematic reviews (11 of 18) were published since 2005, all included studies from high-income countries and five include studies from low- and middle-income countries.
The high quality reviews (those that received between 8 and 11 on the AMSTAR scale) focused on diverse topics. They included reviews of the setting and organization of care for PHAs , various mental health interventions for PHAs (including group psychotherapy and cognitive behavioral interventions) [37–41], interventions to address adherence to highly active anti-retroviral therapy (HAART) [42–44], and interventions to reduce PHA’s HIV risk behaviors [45–47]. The outcomes of these interventions varied depending on their focus. Some of the key findings from these high quality reviews highlighted their limitations. For example, Handford et al.  found that centralizing care in high concentration or high volume settings could lead to improved care outcomes for PHAs, but this evidence is mixed and limited to developed country settings. In addition, Handford et al.  found that case management was associated with improved outcomes but the limited number of studies and the varying definitions of case management leave considerable doubt about how best to implement such programs based on the studies reviewed. Another high-quality review by Himelhoch et al. , examined cognitive behavioral therapy, which was found to be efficacious in treating depressive symptoms among PHAs. However, the underrepresentation of women limited the generalizability of the findings . Crepaz et al.  similarly found that PHAs who received cognitive behavioral interventions showed significant improvement in multiple mental health symptoms. However, immune functioning was not impacted, and the long-term intervention effects were uncertain. Interventions were more likely to achieve success if they incorporated stress management skills training and provided opportunities to practice skills .
High quality reviews about interventions to increase adherence to HAART indicated that these interventions were effective in increasing adherence. The characteristics that promote intervention success include delivery at the individual-level (as opposed to those delivered in groups), duration of 12 weeks or more, and interactive discussions about adherence [42, 43].
A high quality review by Crepaz et al.  about interventions to reduce PHAs risk behavior for HIV identified the following characteristics that significantly reduced unprotected sex: (1) guided by behavioural theory; (2) specifically focused on HIV transmission behaviours; (3) provided skills building; (4) delivered to individuals; (5) delivered by health-care providers or professional counselors; (6) delivered in settings where people living with HIV receive services; (7) delivered in an intensive manner; (8) delivered over a longer duration; and (9) addressed a myriad of issues relating to coping with one’s serostatus, medication adherence, and HIV risk behaviours .
The medium quality reviews (with scores between 4 and 7 on the AMSTAR scale) that addressed topics not covered by the high quality reviews focused on HIV testing and counselling  and stress management interventions . Weinhardt et al.  found that HIV counselling and testing was effective for secondary prevention (i.e., early detection and treatment to limit disease progression and to prevent further HIV transmission) but not for primary prevention (i.e., preventing uninfected individuals from becoming infected). Scott-Sheldon et al.  found that stress management interventions impacted mental health symptoms, but not immunological functioning. This finding was similar to those in the high quality review by Crepaz et al.  which found that cognitive behavioral interventions improved mental health symptoms, but not immunological functioning.
A low-quality review  suggests that stigma, disclosure and self-efficacy are important factors to consider in psychosocial counselling interventions and that treatment teams should be aware of vulnerable periods in the course of HIV illness (e.g., periods of increased symptoms or pain).
The systematic reviews about health promotion (that did not also address counselling and case management) are included in Table 2. Two high-quality reviews found that sustained aerobic and progressive resistance exercise strategies may lead to clinically important improvements for people living with HIV/AIDS [48, 49]. Positive physical outcomes were observed in both reviews, and the aerobic exercise review also observed positive psychological outcomes.
A medium quality review by Mills et al.  assessed the effectiveness of complementary and alternative treatments, and found that mental health therapies (specifically, cognitive behavioural stress management therapies) appeared to be the most promising. A medium-quality review found a positive association between housing stability and better health-related outcomes . The review also found that the receipt of some form of housing assistance was associated with routine use of primary health care services . The review also found that housing instability was a significant predictor of non-adherence to HAART.
Across both domains, the most common areas of focus of the reviews were mental health interventions to support PHAs [37–41], and interventions to address adherence to HIV medications [42–44, 52, 53]. The highest quality reviews with a focus on mental health evidence suggest that cognitive behavioural interventions (including group therapy) were effective at improving symptoms of depression, anxiety and stress (but not immune functioning) [38, 39]. However, as outlined by Crepaz et al. , there is limited evidence about the long-term impact of these types of interventions. The highest quality reviews assessing adherence to HAART [42, 43] found that participants who received an intervention were 1.5 times as likely to report 95 % adherence and 1.25 times as likely to achieve an undetectable viral load. In addition, interventions targeting practical medication management skills, those targeting individuals versus groups and those delivered over 12 weeks or more were most effective at improving adherence. The most recent review, which was of medium-quality, found that drug abuse treatment, psychological characteristics (higher self-esteem) and access to mental health treatment facilitated better adherence to HAART .
Our overview was designed within the framework of helping Canadian national, provincial and local organizations meet their strategic goals related to program and policy development. The purpose of the scoping review was threefold: (1) to identify all systematic reviews related to counselling, case management and health promotion for PHAs, (2) to assess the quality and local applicability of the systematic reviews, and (3) to develop user-friendly summaries and disseminate them among program and policy decision-makers.
This overview found 18 systematic reviews (12 of which conducted a meta-analysis) addressing topics related to counselling, case management and/or health promotions for people living with HIV/AIDS. All of the systematic reviews except one were of medium- or high-quality and a user-friendly summary has been developed for each to support their use by health system stakeholders. The reviews addressed topics related to: setting and organization of care for PHAs; various mental health interventions for PHAs (including group psychotherapy and cognitive behavioral interventions); interventions to address adherence to highly active anti-retroviral therapy (HAART); interventions to reduce PHA’s HIV risk behaviors; aerobic and progressive resistance exercise; and housing stability.
Key findings from high-quality systematic reviews found research evidence to support: centralizing PHA care in high concentration or high volume settings; cognitive behavioural interventions for reducing symptoms of depression, stress and anxiety; interventions to promote adherence (particularly those that provide practical medication management skills, target individuals are delivered over a time-period of 12 weeks or more); and the use of aerobic and progressive resistance exercise.
This overview of systematic reviews has several strengths. First, the methods used in the review are robust as they draw on validated search strategies for identifying systematic reviews and the objectives and process for selecting reviews followed an a priori protocol. Second, all of the included systematic reviews were quality appraised by two independent reviewers using a validated and commonly used tool. Lastly, in an effort to further support the use of the findings, we produced a user-friendly summary for each of the 18 included systematic reviews, which are available at (http://www.hivevidence.org/SHARE/ResourcesSummaries.aspx).
There are two main limitations to our review. First, our review is based on a search from 2009 and therefore may not include systematic reviews that have been completed since then (although we included updated versions of reviews that were originally caught in our search). Second, we conducted assessments of methodological quality of systematic reviews but not assessments of the strength of the evidence included within them. Readers should be aware that a systematic review of high methodological quality could have little utility in terms of the strength of the research evidence it includes. In other words, while a review may be well done, the studies available may be small and/or of low-quality. Lastly, though our process has made research evidence more accessible, decision-makers in community-based HIV/AIDS organizations do not have regular access to the online research databases where the full reviews are located. For example, though the user-friendly summaries provide crucial information in an accessible format, decision-makers may be unable to check the full reviews to clarify any specific issues.
This overview of systematic reviews provides a useful resource for supporting the development and delivery of evidence-informed support services in community settings. Service providers and policy makers can draw on the set of quality appraised and synthesized systematic reviews provided in this overview to rapidly determine whether there is any high-quality synthesized research evidence available about counselling, case management or health promotion for people living with HIV/AIDS. Researchers can use this set of systematic reviews to prioritize areas where updated systematic reviews are needed and work with service providers and policymakers to identify and prioritize areas for new systematic reviews. In addition, the findings from our synthesis also highlight the need to ensure consistent methodological standards in systematic reviews. Registering titles and protocols for systematic reviews and requiring specific quality standards as part of the registration process (as is done by the Cochrane Collaboration and PROSPERO) is a promising mechanism that may help increase the overall quality of reviews.
A remaining challenge or next step is to engage decision-makers in building their capacity to effectively use the available research evidence for program development purposes. Providing information, even in the form of user-friendly summaries, is helpful and necessary. However, a larger challenge is how to use the information in the context of reviewing, renewing or developing programs and policy. This speaks to the sustainability of locating, assessing, synthesizing and disseminating research evidence to decision-makers. Future efforts may examine the sustainability of mobilizing research evidence for decision-makers.
This review was funded through a Grant from the Canadian Institutes of Health Research (Grant number KRS-92531). We would like to thank the members of our advisory committee: Simonne LeBlanc (AIDS Calgary, Canada), Michelle Gill (AIDS New Brunswick, Canada), Tanya Lary (Public Health Agency of Canada), Frank McGee (AIDS Bureau, Ontario Ministry of Health and Long-Term Care) and Ken Monteith (COCQ-SIDA). We would also like to thank Joe Manson for helping with the initial review of the titles and abstracts.
Sergio Rueda is the lead author of one of the systematic reviews included in our analysis.
This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
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|49..||O’Brien K, Nixon S, Tynan AM, Glazier R. Aerobic exercise interventions for adults living with HIV/AIDS. Cochrane Database Syst Rev 2010;8:CD001796.|
|50..||Mills E,Wu P,Ernst E. Complementary therapies for the treatment of HIV: in search of the evidenceInt J STD AIDSYear: 200516639540210.1258/095646205409396215969772|
|51..||Leaver CA,Bargh G,Dunn JR,Hwang SW. The effects of housing status on health-related outcomes in people living with HIV: a systematic review of the literatureAIDS BehavYear: 200711Supplement 28510010.1007/s10461-007-9246-317682940|
|52..||Crepaz N,Hart TA,Marks G. Highly active antiretroviral therapy and sexual risk behavior: a meta-analytic reviewJAMAYear: 2004292222423610.1001/jama.292.2.22415249572|
|53..||Malta M,Strathdee SA,Magnanini MMF,Bastos FI. Adherence to antiretroviral therapy for human immunodeficiency virus/acquired immune deficiency syndrome among drug users: a systematic reviewAddictionYear: 200810381242125710.1111/j.1360-0443.2008.02269.x18855813|
[Figure ID: Fig1]
Flow diagram of study selection
Included systematic reviews about counselling and case management
|Review||Domain/topics studied||Focus of review||Key findings||Year of last search||AMSTAR (quality) rating||Countries in which included studies were conducted|
|Handford et al. ||Organization (including case management) and setting of care||To evaluate the association between the setting and organization of care and outcomes for people living with HIV/AIDS||Centralizing care in high concentration/high volume centres could lead to improved outcomes including mortality, but this evidence is mixed and limited to developed country settings
Case management may be associated with improved outcomes but the limited number of studies and the varying definitions of case management leave considerable doubt about how best to implement such programs
Multidisciplinary and multi-faceted treatments, health information systems and extended hours of operation are promising interventions but evidence about their effectiveness is so far lacking
|Himelhoch et al. b||Counselling
|To examine the efficacy of group psychotherapy treatment among HIV infected with depressive symptoms||Group therapy (particularly group cognitive behavioral therapy) may be efficacious in treating depressive symptoms among PHAs; however, the underrepresentation of women in the included studies limits the generalizability of the reviews findings
Because women may be at risk for depression and are an emerging population at risk for HIV (in high income countries), future studies should address this issue
|2006||9/11||Low- and middle-income countries (0)
High-income countries (8): United States (6); Netherlands (1); China (Hong Kong) (1)
|Rueda et al. b||Counselling
Medication management and adherence
Sexual health/risk behaviours
|To assess the effectiveness of patient support and education to improve adherence to highly active antiretroviral therapy||Intervention features that were linked to successful adherence outcomes included those: targeting practical medication management skills, administered to individuals vs. groups, and delivered over 12 weeks or more; but not those targeting more complex psychological constructs or targeting marginalized populations such as women, Latinos, or patients with a past history of alcoholism
This review did not find any studies that examined the effectiveness of provider-level interventions (e.g., those interventions that provide feedback to practitioners) and system-level interventions (e.g., those interventions that address access and affordability to services)
Future efforts need to examine the impact of the patient-provider relationship and the clinical setting on adherence, in addition to the generalizability of results to a wider range of populations
|2005||9/11||Low- and middle-income countries (0)
High-income countries (19): United States (12); Spain (2); France (2); Australia (2); Switzerland (1)
|Crepaz et al. b||Counselling
|To assess interventions for people living with HIV to determine their overall efficacy in reducing HIV risk behaviours and identify intervention characteristics associated with efficacy||The interventions were found to successfully reduce self-reported unprotected sex and STI acquisition, but not needle sharing, among PHAs
Interventions with the following characteristics were found to significantly reduce unprotected sex: (1) guided by behavioural theory; (2) specifically focused on HIV transmission behaviours; (3) provided skills building; (4) delivered to individuals; (5) delivered by health-care providers or professional counselors; (6) delivered in settings where people living with HIV receive services; (7) delivered in an intensive manner; (8) delivered over a longer duration; (9) addressed a myriad of issues relating to coping with one’s serostatus, medication adherence, and HIV risk behaviours
|2004||9/11||Low- and middle-income countries (0)
High-income countries (14): United States (10); China (Hong Kong) (2); Canada (1); Netherlands (1);
Not reported (1)
|Crepaz et al. b||Counselling
Immune system functioning
|To evaluate the efficacy of cognitive-behavioral interventions (CBIs) for improving the mental health and immune functioning of people living with HIV||PHAs who received CBIs showed a significant improvement in symptoms of depression, anxiety, anger, and stress, but not in immune functioning relative to controls
No long-term evidence for significant intervention effects on symptoms of depression and anxiety, suggesting on-going behavioral reinforcement needed to prevent relapse
CBIs for PHAs are more likely to achieve success if interventions incorporate stress management skills training and provide opportunities to practice skills
|2005||8/11||Low- and middle-income countries (0)
High-income countries (15): United States (11); China (Hong Kong) (2); Canada (1); Netherlands (1)
|Simoni et al. b||Counselling
Adherence to highlight active retroviral therapy
|To examine whether behavioral interventions addressing highly active antiretroviral adherence are successful in increasing the likelihood of a patient attaining 95% adherence or an undetectable HIV-1 RNA viral load||The most common intervention delivery method for HAART adherence was 1-on-1 counselling and group counselling, with the most common interveners being health care providers (physicians and nurses) or mental health counselors (psychologists)
Participants who received an intervention were 1.5 times as likely to report 95 % adherence and 1.25 times as likely to achieve an undetectable viral load, relative to control participants
Intervention effect sizes are: significantly stronger in studies that used a longer recall period (i.e., 2 weeks or 1 month) versus a shorter one (i.e., ≤7 days) for 95 % adherence; and larger in studies that provided didactic information on HAART and studies that included interactive discussions regarding adherence
These findings suggest the importance of providing basic information to patients and engaging patients in discussions to help overcome cognitive factors (e.g., avoidance coping), lack of motivation, and unrealistic expectations about adherence behaviours
|2005||8/11||Low- and middle-income countries (0)
High-income countries (19): United States (14); France (2); Spain (2); Switzerland (1)
|Moskowitz et al. b||Counselling
|To determine which types of coping are related to psychological and physical well-being among people with HIV and whether contextual, measurement, or individual variables affect the extent to which coping is related to physical and psychological well-being||Direct action and positive reappraisal were consistently associated with better outcomes in PHAs across affective health behaviours, and physical health categories
Disengagement forms of coping, such as behavioral disengagement and use of alcohol or drugs to cope, were consistently associated with poorer outcomes
In some cases, coping effectiveness was dependent on contextual factors, including time since diagnosis and the advent of HAART
|Johnson et al. a,b||Counselling
HIV/AIDS information or education
Sexual health/risk behaviour
|To assess interventions to reduce HIV + individuals’ sexual risk||Behavioural interventions reduced sexual risk especially if they included motivational and skills components
Such interventions have been less effective for older samples, suggesting the need for further refinement to enhance their efficacy
Motivation and skill-based interventions have not yet been tested with HIV+ MSM who, in general, seem to have benefited less from extant risk reduction interventions
|2004||5/10||Low- and middle-income countries (1): Tanzania (1)
High-income countries (14): United States (14)
|Weinhardt et al. b||Counselling
|To examine whether HIV counselling and testing (HIV-CT) leads to reductions in sexual risk behavior||HIV-CT appears to provide an effective means of secondary, but not primary, prevention of HIV infection
Theory-driven research is needed to further explicate the determinants of behavior change in HIV-CT and empirically-driven research is needed to examine the effectiveness of specific counselling approaches with different content, modes of delivery, and levels of intensity
HIV-CT is one part of an overall HIV prevention strategy that also includes individual-, community-, and policy-level interventions
|1997||5/10||Low- and middle-income countries (6): Rwanda (2); Kenya (1); Zaire (1); Uganda (1); The Gambia (1)
High-income countries (21): United States (18); Netherlands (1); Italy (1); Canada (1)
|Simoni et al. a||Counselling
Adherence to highly active retroviral therapy for pediatric infection
|Adherence to antiretroviral therapy for pediatric HIV infection||Medication related factors significantly associated with adherence include: twice-per-day (vs 3-times per day) nelfinavir regimen; shorter length of time since treatment initiation; nelfinavir rather indinavir
Patient related factors significantly associated with adherence include: Nonwhite (vs white) race; both younger and older age of child; children’s unawareness of their HIV diagnosis; beliefs regarding the positive impact of the medications on quality of life; lower intensity of alcohol use; housing stability; less depressive symptomatology; less child stress; decreased child responsibility for medications; improved health status/virologic or immunologic factors
Caregiver/family related factors significantly associated with adherence include: Foster (vs biological) parent; higher self-efficacy; belief in the efficacy of the medication; less concern about hiding child’s diagnosis; better parent-child communication; less caregiver stress; higher quality of life; better caregiver cognitive functioning; better caregiver knowledge of antiretroviral medications; fewer barriers
The review fails to provide definitive guidelines or to identify any gold standard for adherence assessment methods. The limitations of any single assessment strategy highlight the need to develop multi-systemic, cost-effective approach to assess and improve adherence to antiretroviral therapy for children with HIV
|2005||4/10||Low- and middle-income countries (4): Brazil (1); South Africa (1); Cote d’Ivoire (1); Puerto Rico (1)
High-income countries (28): United States (21); Italy (4); Belgium (1); Australia (1); Netherlands (1)
Not reported (1)
|Scott-Sheldon et al. b||Counselling
Mental health (depression, coping, stress management)
|To examine the impact of stress-management interventions at improving psychological, immunological, hormonal, and other behavioral health outcomes among HIV positive adults||Stress-management interventions for HIV+ adults significantly improve mental health, fatigue and quality of life but do not improve stress, immunological or hormonal outcomes
The absence of immunological or hormonal benefits may reflect the studies’ limited assessment period (measured typically within 1-week post intervention), participants’ advanced stage of HIV (HIV+ status known for an average of 5 years), the inclusion/exclusion of participants using ART, the lack of information regarding ART adherence, and/or sample characteristics
Future research should examine more diverse samples and patient characteristics that might moderate intervention efficacy, in addition to using lengthier assessment periods to understand better the impact of stress-management interventions for HIV+ adults
|2007||4/11||Not reported in detail (77 % of 35 articles were conducted in the United States)|
|Collins et al. a||Counselling
|To examine the mental health risk factors for HIV, mental health consequences of HIV, psychosocial interventions of relevance for HIV-infected and affected populations||Stigma, disclosure and self-efficacy were found to have particular relevance for the successful implementation of these programs, in addition to economic factors
Counselling and treatment teams should be aware of vulnerable periods in the course of HIV illness (e.g., periods of increased symptoms or pain) during which patients may have a greater need for support or be at greater risk for experiencing symptoms of mental illness.
There is a need for methodologically sound studies of mental health throughout the course of HIV and interventions that employ identified variables (e.g., coping, family support) for efficacy in reducing symptoms of mental health
|2005||2/10||Low- and middle-income countries (36): India (7); South Africa (5); Thailand (5); Brazil (4); Uganda (4); Kenya (2); Rwanda (2); Taiwan (2); Zaire (2); Zimbabwe (2); China (1); Costa Rica (1); Nepal (1); Russia (1); Tanzania (1); Trinidad and Tobago (1)
High-income countries (3): Germany (2); China (Hong Kong) (1)
bThese reviews conducted a meta-analysis as part of their analysis
Included systematic reviews about health promotion
|Review||Domain/topics studied||Focus of review||Key findings||Year of last search||AMSTAR (quality) rating||Countries in which included studies were conducted|
|O’Brien et al. a||Health promotion
|To examine the safety and effectiveness of aerobic exercise interventions on immunological/virological, cardiopulmonary and psychological parameters in adults living with HIV/AIDS||Performing aerobic exercise or a combination of aerobic exercise and resistive exercise for at least 20 minutes, at least three times per week for at least five weeks appears to be safe and may improve fitness, body composition, and well-being for HIV+ adults
Statistically significant improvements were found for some outcomes of cardiopulmonary outcomes (VO2max), body composition (leg muscle area, percent body fat), and psychological status (depression-dejection subscale of the POMS)
The review also found a trend towards potential clinically important improvements in cardiopulmonary fitness and psychological status; however, these findings should be interpreted cautiously due to missing follow-up data or the exclusion of exercisers who did not follow their regimen
|O’Brien et al. a||Health promotion
|To examine the safety and effectiveness of progressive resistive exercise interventions on weight, body composition, strength, immunological/virological, cardiopulmonary and psychological parameters in adults living with HIV infection||Performing progressive resistive exercise or a combination of progressive resistive and aerobic exercise three times a week for at least four weeks appears to be safe and may lead to statistically significant and possible clinically important improvements in body weight and composition for medically stable adults living with HIV/AIDS||2003||10/11||Not reported|
|Mills et al. ||Health promotion
Alternative and complementary therapy
|To assess the effectiveness of complementary and alternative medicine treatments in HIV/AIDS and HIV-associated symptoms||Despite the widespread use of complementary therapies and alternative medicines by PHAs, few large-scale, methodologically sound clinical trials have been conducted to establish their effectiveness
The majority of treatments tested in this review were supportive rather than curative in nature, with cognitive behavioural stress management therapies appearing to be the most promising treatment option for improving anxiety and quality of life
|Crepaz et al. a||Health promotion
|To determine whether (1) being treated with HAART, (2) having an undetectable viral load, or (3) holding specific beliefs about HAART and viral load are associated with increased likelihood of engaging in unprotected sex||HIV+ patients receiving HAART did not exhibit increased sexual risk behaviour whether their treatment achieved an undetectable viral load or not
Beliefs about HAART and viral load were associated with unprotected sexual behaviour
Disease severity beliefs and medical factors such as length of time receiving HAART and stage of disease may help explain increases in unprotected sexual behavior
Recommended that HIV and STI patients should receive prevention messages emphasizing that having an undetectable viral load does not eliminate the possibility of transmitting HIV
|2003||6/11||Low- and middle-income countries (0)
High-income countries (24) United States (15); France (4); England (3); Australia (2); Canada (1); Netherlands (1); Switzerland (1)
Not reported (1)
|Malta et al. ||Health promotion
Adherence to antiretroviral therapy
|To identify factors associated with non-adherence to HIV treatment among HIV-positive drug users||Facilitators of HAART adherence among HIV+ drug users include access to drug abuse treatment (e.g., substitution therapy for opiate addiction), psychological characteristics (e.g., higher self-esteem, adherence self-efficacy), and access to mental health treatment
Illicit stimulant use, social instability (e.g., unemployment, homelessness), and psychological problems (e.g., anxiety, depression) represents a key challenge for optimal adherence
Review findings support the need for low-threshold/user-friendly health care delivery systems targeted to the specific needs of HIV+ drug users to optimize adherence, such as drug treatment, case-management, medical services and psychosocial supports
|2007||4/11||Low- and middle-income countries (0)
High-income countries (41) United States (22); Canada (8); France (6); Spain (3); Ireland (1); Italy (1)
|Leaver et al. ||Health promotion
Adherence and access/utilization of health care
|To assess the effects of housing status on health-related outcomes in people living with HIV/AIDS||Increased housing stability was significantly correlated with better health-related outcomes, as measured by medication adherence, utilization of health and social services, health status, and HIV risk behaviours
The receipt of some form of housing assistance was found to be significantly associated with routine use of primary health care services, and housing instability was found to be a significant predictor of non-adherence to HAART
|2005||4/10||Low- and middle-income countries (1) Cote d’Ivoire (1)
High-income countries (28) United States (22); Canada (1); European Union (4) [France (1), Spain (1), Not reported (2)]; Australia (1)
Table 1 contains three reviews (each identified under footnote a) that address health promotion but are only presented in that table
aThese reviews conducted a meta-analysis as part of their analysis
Keywords: Keywords HIV, Systematic review, Case management, Health promotion, Counselling.
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