| Coumarins from Cnidium monnieri and their antiosteoporotic activity. | |
| | |
MedLine Citation:
|
PMID: 17315308 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Bioactivity-guided fractionation has led to the successful isolation of antiosteoporotic components, i. e., osthole, imperatorin and bergapten from an ethanolic extract of the fruits of Cnidium monnieri (L.) Cusson. Among them, osthole was determined as the major compound possessing antiosteoporotic activity. Further study showed that osthole not only promoted the proliferation and activity of alkaline phosphatase of osteoblasts in neonatal calvaria cultures, but also inhibited the bone resorption by decreasing the formation, differentiation and TRAP activity of osteoclasts derived from rat marrow cells. |
| | |
Authors:
|
Qiaoyan Zhang; Luping Qin; Weidong He; Luc Van Puyvelde; Dominick Maes; An Adams; Hanchen Zheng; Norbert De Kimpe |
Related Documents
:
|
17266398 - Endogenous pki gamma limits the duration of the anti-apoptotic effects of pth and beta-... 11257458 - Pth stimulates plcbeta and plcgamma isoenzymes in rat enterocytes: influence of ageing. 17311298 - Osterix is a key target for mechanical signals in human thoracic ligament flavum cells. 14769788 - In vitro effects of dentin matrix protein-1 on hydroxyapatite formation provide insight... 2768268 - Phosphorylation of ferredoxin and regulation of renal mitochondrial 25-hydroxyvitamin d... 22272708 - The pim kinases in hematological cancers. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Planta medica Volume: 73 ISSN: 0032-0943 ISO Abbreviation: Planta Med. Publication Date: 2007 Jan |
Date Detail:
|
Created Date: 2007-02-21 Completed Date: 2007-03-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0066751 Medline TA: Planta Med Country: Germany |
Other Details:
|
Languages: eng Pagination: 13-9 Citation Subset: IM |
Affiliation:
|
Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alkaline Phosphatase
/
biosynthesis Animals Bone Marrow Cells / drug effects, metabolism Cell Proliferation / drug effects* Cnidium* Dose-Response Relationship, Drug Fruit Osteoblasts / drug effects*, metabolism Osteoporosis / drug therapy Phytotherapy* Plant Extracts / administration & dosage, pharmacology*, therapeutic use Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
|
0/Plant Extracts; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical effects produced by a standardized herbal medicinal product of Hibiscus sabdariffa on patie...
Next Document: Identification of a new natural camptothecin analogue in targeted screening for HIF-1alpha inhibitor...