| Coumarin effects on amino acid levels in mice prefrontal cortex and hippocampus. | |
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MedLine Citation:
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PMID: 19429071 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coumarin is a compound known to be present in a wide variety of plants, microorganisms and animal species. Most of its effects were studied in organs and systems other than the central nervous system. The present work evaluated the effect of coumarin administration on the levels of gamma-aminobutyric acid (GABA), glutamate (GLU), glycine (GLY) and taurine (TAU) in the prefrontal cortex and hippocampus of mice. Male Swiss mice were treated with distilled water (controls), coumarin (20 or 40 mg/kg, i.p.) or diazepam (1 mg/kg, i.p.). Results showed that in the prefrontal cortex, coumarin at the lowest dose increased the levels of GLU and TAU, while GABA increased with both doses studied and GLY had its levels increased only at the dose of 40 mg/kg. Diazepam (DZP) increased the levels of GABA and TAU and decreased the levels of GLU and GLY in this area. In the hippocampus, only glutamate had its levels decreased after coumarin treatment, while diazepam increased the levels of GABA and TAU and decreased the levels of GLU in this brain region. We concluded that coumarin stimulates the release of endogenous amino acids, increasing the levels of inhibitory and excitatory amino acids in the prefrontal cortex, and decreasing glutamate levels in the hippocampus. Together, these results are of interest, considering that some neurodegenerative diseases and seizures are related to the imbalance of the amino acid levels in the CNS suggesting a perspective of a therapeutic use of coumarins in these disorders. |
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Authors:
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Elaine Cristina Pereira; Daniel Luna Lucetti; José Maria Barbosa-Filho; Eliane Magalhães de Brito; Valdécio Silvano Monteiro; Manoel Cláudio Azevedo Patrocínio; Rebeca Ribeiro de Moura; Luzia Kalyne Almeida Moreira Leal; Danielle Silveira Macedo; Francisca Cléa Florenço de Sousa; Glauce Socorro de Barros Viana; Silvânia Maria Mendes Vasconcelos |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-03-06 |
Journal Detail:
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Title: Neuroscience letters Volume: 454 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-05-11 Completed Date: 2009-08-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 139-42 Citation Subset: IM |
Affiliation:
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Department of Physiology and Pharmacology, Federal University of Ceará, Rua Cel. Nunes de Melo 1127, CEP 60431-270, Fortaleza, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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analysis* Analysis of Variance Animals Central Nervous System Agents / pharmacology* Chromatography, High Pressure Liquid Coumarins / pharmacology* Diazepam / pharmacology Dose-Response Relationship, Drug Glutamic Acid / analysis Glycine / analysis Hippocampus / chemistry, drug effects* Male Mice Prefrontal Cortex / chemistry, drug effects* Taurine / analysis gamma-Aminobutyric Acid / analysis |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Central Nervous System Agents; 0/Coumarins; 107-35-7/Taurine; 439-14-5/Diazepam; 56-12-2/gamma-Aminobutyric Acid; 56-40-6/Glycine; 56-86-0/Glutamic Acid; 91-64-5/coumarin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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