Document Detail

Coumarin derivatives protection against ROS production in cellular models of Abeta toxicities.
MedLine Citation:
PMID:  17886039     Owner:  NLM     Status:  MEDLINE    
The role of oxidative stress and free radicals in the development of Alzheimer's disease (AD) has been the focus of many recent studies. The role of hydrogen peroxide (H(2)O(2)) in AD is thought to be associated with Abeta (amyloid - beta) damage in cells. A number of coumarin derivatives were previously found to be potent anti-inflammatory and antioxidant agents. Herein, these coumarin derivatives were tested as H(2)O(2) scavengers with the DCF assay using two types of neuronal cells: (a) wild type (N2a) neuroblastoma cells and (b) APP/PS1 transgenic cell line expressing Abeta. Their scavenging activity was varied between the types of cell cultures and it was found to be concentration and time dependent in the mutant cells. Their protective role against cell death further supports this notion. These results suggest that these compounds could be used as a template in the design of new molecules with a possible role in AD.
Christos A Kontogiorgis; Yanan Xu; Dimitra Hadjipavlou-Litina; Yuan Luo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Free radical research     Volume:  41     ISSN:  1071-5762     ISO Abbreviation:  Free Radic. Res.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-21     Completed Date:  2007-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1168-80     Citation Subset:  IM    
Aristotle University of Thessaloniki, School of Pharmacy, Department of Pharmaceutical Chemistry, Thessaloniki, Greece.
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MeSH Terms
Alzheimer Disease / metabolism
Amyloid beta-Protein / chemistry*
Cell Line, Tumor
Coumarins / chemistry,  pharmacology*
Free Radicals
Hydrogen Peroxide / chemistry,  pharmacology
Mice, Transgenic
Models, Chemical
Oxidative Stress
Reactive Oxygen Species*
Tetrazolium Salts / pharmacology
Thiazoles / pharmacology
Reg. No./Substance:
0/Amyloid beta-Protein; 0/Coumarins; 0/Free Radicals; 0/Reactive Oxygen Species; 0/Tetrazolium Salts; 0/Thiazoles; 298-93-1/thiazolyl blue; 7722-84-1/Hydrogen Peroxide; 91-64-5/coumarin

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