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Could thrombocyte parameters be an inflammatory marker in the brucellosis?
MedLine Citation:
PMID:  23348158     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Aim To investigate links between platelet parameters mean platelet volume (MPV), platelet count (PC), platelet distribution width (PDW), platelet mass (PM) and brucella tube agglutination titers (BSTAT) in patients with brucellosis. Initially, PC, MPV, PM and PDW calculations were compared between periods before and after treatment. The correlation between inlammation markers (erythrocyte sedimentation rate, ESR, white blood cell count, WBC, and C reactive protein, CRP) and platelet parameters was subsequently investigated. Methods This self-controlled study included 40 patients who had positive BSTAT at least at a titer of 1/160. Platelet parameters and inlammation values (CRP, ESR) at the time of positive BSTAT at least at a titer of 1/160 (pre-treatment) were compared with control of the same parameters at the time when BSTAT became negative or when the titers reduced 4 folds (post-treatment). Results Mean platelet volume values (7.90+1.96) were signiicantly elevated in post treatment period when compared to pre treatment (7.58+1.96), (p= 0.023). Post treatment CRP, ESR and PC were signiicantly reduced when compared to pretreatment values (p=0.000, p=0.000 and p=0.025, respectively). In the pretreatment period, a direct correlation between ESR and PC values (r=0.036, p=0.025), and inverse correlations between ESR with MPV (r=-0.337, p=0.038) was found. A dependent predictive factor in multivariate logistic regression analysis for BSTAT was not found.
Authors:
Abdulkadir Küçükbayrak; Tekin Taş; Mehmet Tosun; Gülali Aktaş; Aytekin Alçelik; Ismail Necati Hakyemez; Esra Koçoğlu; Hayrettin Akdeniz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina     Volume:  10     ISSN:  1840-0132     ISO Abbreviation:  Med Glas Ljek komore Zenicko-doboj kantona     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101250177     Medline TA:  Med Glas Ljek komore Zenicko-doboj kantona     Country:  Bosnia and Hercegovina    
Other Details:
Languages:  eng     Pagination:  35-9     Citation Subset:  IM    
Affiliation:
1Department of Infectious Diseases and Clinical Microbiology, 2Department of Medical Microbiology, 3Department of Biochemistry, 4Department of Internal Medicine; Abant Izzet Baysal University, School of Medicine, Bolu, Turkey.
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