Document Detail


Could tendinosis be involved in osteoarthritis?
MedLine Citation:
PMID:  21410541     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Ten patients, age 60 (48-75 years), with osteoarthritis (OA) of the hip and 10 patients, age 82.5 (60-90 years), with fracture of the collum femoris (FCF; minimum Garden stage III) underwent an open biopsy procedure from the internal obturator tendon in conjunction with a total hip replacement. The histological evaluation revealed that all tendon samples in the OA group revealed scar tissue; the corresponding was found in 50% of patients in the FCF group (P=0.02). There were also more GAGs (P=0.023) and calcium deposits (P=0.001) in the samples from the OA group. The ultrastructural evaluation revealed fewer small and medium-sized fibrils (P=0.001) and more non-collagenous extracellular matrix (ECM) (P=0.003) in the OA group. Taken together, the samples from the internal obturator tendon in the OA group revealed a more degenerative appearance with more scar tissue, change in fibril diameter distribution and more non-collagenous ECM. Our findings suggest that OA and periarticular tendinopathy are closely linked. Further research is needed to determine whether musculotendinous changes in the deep rotators are sequelae of joint pathology, or a contributing factor in the development of degenerative joint change.
Authors:
K Meknas; O Johansen; S E Steigen; R Olsen; L Jørgensen; J Kartus
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-16
Journal Detail:
Title:  Scandinavian journal of medicine & science in sports     Volume:  -     ISSN:  1600-0838     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111504     Medline TA:  Scand J Med Sci Sports     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Affiliation:
Department of Orthopedics, University Hospital of Northern Norway, Tromsø, Norway Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway Diagnostic Clinic - Clinical Pathology, University Hospital of Northern Norway, Tromsø, Norway Institute of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway Department of Electron Microscopy, Institute of Medical Biology, University of Tromsø, Tromsø, Norway Department of Orthopedics, NU - Hospital Organization, Trollhättan/Uddevalla, Sweden.
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