| Could sudden cardiac death in epilepsy be related to the occurrence of thalamic dysfunction or anatomic change? | |
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MedLine Citation:
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PMID: 19330235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sudden unexpected death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of death in people with chronic epilepsy. Its physiopathology is still unknown; however, the most commonly suggested potential mechanisms involve cardiac or respiratory abnormalities. As the anatomical substrate of epileptic activity in the central nervous system (CNS) shows a direct relationship with cardiovascular alterations, this may suggests that patients with epilepsy associated with focal CNS lesions may be at particular risk of SUDEP. Currently, experimental and clinical data support an important role for thalamic nuclei in the behavioural manifestations, initiation and propagation of seizures. In view of the above findings, we purpose that SUDEP, at least in some cases, could be related to the occurrence of thalamic dysfunction or anatomic change. |
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Authors:
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Fulvio A Scorza; Lineu Calderazzo; Marly de Albuquerque; Ricardo M Arida; Antonio-Carlos G de Almeida; Esper A Cavalheiro |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Arquivos de neuro-psiquiatria Volume: 67 ISSN: 1678-4227 ISO Abbreviation: Arq Neuropsiquiatr Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-30 Completed Date: 2010-02-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0125444 Medline TA: Arq Neuropsiquiatr Country: Brazil |
Other Details:
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Languages: eng Pagination: 139-43 Citation Subset: IM |
Affiliation:
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Disciplina de Neurologia Experimental, Escola Paulista de Medicina, Universidade Federal de S?o Paulo, S?o Paulo, SP, Brasil. scorza.nexp@epm.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Death, Sudden, Cardiac*
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etiology,
pathology Epilepsy* / complications, physiopathology Heart Rate / physiology Humans Risk Factors Thalamic Diseases* / complications, physiopathology Thalamus* / pathology, physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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