| Could reduced cerebrospinal fluid (csf) galanin contribute to restricted eating in anorexia nervosa? | |
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MedLine Citation:
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PMID: 11331150 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Galanin (GAL) and gamma amino butyric acid (GABA) are orexigenic neuropeptides that could contribute to the pathogenesis of anorexia nervosa (AN). To avoid the confounding effects of the ill state, we studied women who were recovered (> 1 year, normal weight, and regular menstrual cycles, no binging or purging) from AN (REC AN) and matched healthy control women (NC). CSF GAL was reduced in REC AN (64.4 +/- 8.6 pg/ml) compared to NC (72.0 +/- 11.6 pg/ml; p <.05), GABA was similar between groups. In the brain, GAL stimulates appetite and fat consumption. These data raise the question of whether alterations in brain GAL activity plays a role in clinical symptoms in AN, such as food restriction and fat avoidance. |
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Authors:
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G K Frank; W H Kaye; A Sahu; J Fernstrom; C McConaha |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Volume: 24 ISSN: 0893-133X ISO Abbreviation: Neuropsychopharmacology Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-05-01 Completed Date: 2001-07-19 Revised Date: 2011-05-18 |
Medline Journal Info:
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Nlm Unique ID: 8904907 Medline TA: Neuropsychopharmacology Country: United States |
Other Details:
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Languages: eng Pagination: 706-9 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anorexia Nervosa / cerebrospinal fluid*, physiopathology Body Weight / physiology Down-Regulation / physiology Eating / physiology* Female Galanin / cerebrospinal fluid*, deficiency* Humans Hypothalamus / metabolism, physiopathology gamma-Aminobutyric Acid / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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2 R01 MH 42984-04/MH/NIMH NIH HHS; 2 R01 MH 46001-07A1/MH/NIMH NIH HHS; 5M01RR00084/RR/NCRR NIH HHS; HD24730/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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56-12-2/gamma-Aminobutyric Acid; 88813-36-9/Galanin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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