Document Detail

Could reduced cerebrospinal fluid (csf) galanin contribute to restricted eating in anorexia nervosa?
MedLine Citation:
PMID:  11331150     Owner:  NLM     Status:  MEDLINE    
Galanin (GAL) and gamma amino butyric acid (GABA) are orexigenic neuropeptides that could contribute to the pathogenesis of anorexia nervosa (AN). To avoid the confounding effects of the ill state, we studied women who were recovered (> 1 year, normal weight, and regular menstrual cycles, no binging or purging) from AN (REC AN) and matched healthy control women (NC). CSF GAL was reduced in REC AN (64.4 +/- 8.6 pg/ml) compared to NC (72.0 +/- 11.6 pg/ml; p <.05), GABA was similar between groups. In the brain, GAL stimulates appetite and fat consumption. These data raise the question of whether alterations in brain GAL activity plays a role in clinical symptoms in AN, such as food restriction and fat avoidance.
G K Frank; W H Kaye; A Sahu; J Fernstrom; C McConaha
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  24     ISSN:  0893-133X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-05-01     Completed Date:  2001-07-19     Revised Date:  2011-05-18    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  706-9     Citation Subset:  IM    
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA.
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MeSH Terms
Anorexia Nervosa / cerebrospinal fluid*,  physiopathology
Body Weight / physiology
Down-Regulation / physiology
Eating / physiology*
Galanin / cerebrospinal fluid*,  deficiency*
Hypothalamus / metabolism,  physiopathology
gamma-Aminobutyric Acid / metabolism*
Grant Support
2 R01 MH 42984-04/MH/NIMH NIH HHS; 2 R01 MH 46001-07A1/MH/NIMH NIH HHS; 5M01RR00084/RR/NCRR NIH HHS; HD24730/HD/NICHD NIH HHS
Reg. No./Substance:
56-12-2/gamma-Aminobutyric Acid; 88813-36-9/Galanin

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