| Could lipid infusion be a risk for parenteral nutrition-associated cholestasis in low birth weight neonates? | |
| | |
MedLine Citation:
|
PMID: 17436017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To assess whether lipid infusion could be a risk factor for parenteral nutrition-associated cholestasis (PNAC) in low birth weight neonates, 22 newborns with cholestasis (29.8 +/- 1.6 weeks, 1298 +/- 217 g) were compared with 22 without cholestasis (29.5 +/- 1.7 weeks, 1286 +/- 363 g). The mean level of peak direct bilirubin for the cholestasis group was 4.6 mg/dl compared to 1.2 mg/dl for the noncholestasis group. A univariate analysis revealed that PNAC was significantly related to duration of fasting (p = 0.008) and parenteral nutrition (p < 0.0001), days of antibiotics use (p = 0.025), positive C-reactive protein (p = 0.018) or gastric culture (p = 0.018), and feeding intolerance (p < 0.0001). Total amino acid amount (p < 0.0001), total lipid amount (p < 0.0001), and average daily lipid amount (p = 0.002) were significantly higher in the cholestasis group than in the noncholestasis group. Conversely, prenatal administration of dexamethasone was a significant protective factor of PNAC (p = 0.008). Logistic regression analysis revealed that the cumulative amount of lipid infusion was an independent risk factor for PNAC (p = 0.041; OR 1.174; CI 1.007-1.369). We suggest that decreasing the cumulative load of amino acids and intralipids with early trophic feeding, control of infection, and prenatal administration of dexamethasone could possibly attenuate the severity of PNAC. |
| | |
Authors:
|
Jae Il Shin; Ran Namgung; Min Soo Park; Chul Lee |
Related Documents
:
|
10901427 - Lipid and fatty acid composition and energy partitioning during embryo development in t... 14535847 - Fatty acids enhance membrane permeabilization by pro-apoptotic bax. 8157617 - Analysis of the lipid moiety of lipopolysaccharide from rhizobium tropici ciat899: iden... 94827 - Effect of evisceration on the disposal of [14c] palmitate in the rat. 566327 - Selenium-sulfur analogues. 1. synthesis and biochemical evaluation of selenotetramisole. 8687397 - Characterization of the inhibitory effects of bile acids on very-low-density lipoprotei... |
Publication Detail:
|
Type: Journal Article Date: 2007-04-14 |
Journal Detail:
|
Title: European journal of pediatrics Volume: 167 ISSN: 1432-1076 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 2008 Feb |
Date Detail:
|
Created Date: 2007-12-24 Completed Date: 2008-05-22 Revised Date: 2009-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: Germany |
Other Details:
|
Languages: eng Pagination: 197-202 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Yonsei University College of Medicine, Severance Children's Hospital, 134 Shinchon-Dong, Seodaemun-Ku, C.P.O. Box 8044, 120-752, Seoul, South Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cholestasis
/
etiology* Energy Intake Humans Infant, Low Birth Weight* Infant, Newborn Infant, Premature, Diseases / therapy Infant, Small for Gestational Age Lipids / administration & dosage*, adverse effects Logistic Models Multivariate Analysis Parenteral Nutrition / adverse effects* Retrospective Studies Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Lipids |
| Comments/Corrections | |
Comment In:
|
Eur J Pediatr. 2009 Jan;168(1):123; author reply 125
[PMID:
18575888
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Is Familial Mediterranean Fever a thrombotic disease or not?
Next Document: Effects of silymarin on the spontaneous proliferation and cell cycle of human peripheral blood leuke...