Document Detail

Could hyperoxic ventilation impair oxygen delivery in septic patients?
MedLine Citation:
PMID:  17445069     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: In critically ill patients, a decrease in whole body oxygen consumption under hyperoxia has been reported and this could be related to hyperoxia-induced arterial changes. We investigated changes in brachial artery circulation and tone during short-term hyperoxic ventilation in septic patients. DESIGN AND SETTING: Prospective clinical study in the intensive care unit of a university hospital. PATIENTS: Fourteen patients (severe sepsis n=3 and septic shock n=11) requiring mechanically controlled ventilation due to sepsis syndrome were investigated under stable clinical conditions. INTERVENTIONS: After a 20-min period of hyperoxic ventilation (inspired oxygen fraction = 100%), two-dimensional images of brachial artery cross-sectional area and brachial blood flow velocities were recorded using conventional ultrasonography and pulsed Doppler simultaneously with invasive arterial pressure measurements. MEASUREMENTS AND MAIN RESULTS: Hyperoxia did not affect heart rate, but increased mean arterial pressure and decreased cross-sectional areas both at the end of diastole and at the end of systole. Haemodynamic study showed an increase in resistance index, and a decrease in distensibility and compliance coefficients. Furthermore, a decrease in brachial artery blood flow and arterial oxygen delivery was observed during hyperoxic exposure. CONCLUSIONS: Hyperoxia was paradoxically demonstrated to decrease oxygen delivery in upper limbs during septic shock.
Pascal Rossi; Laurent Tauzin; Michel Weiss; Jean-Claude Rostain; Jean-Marie Sainty; Alain Boussuges
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  27     ISSN:  1475-0961     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-20     Completed Date:  2007-06-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  180-4     Citation Subset:  IM    
Laboratoire de Physiopathologie et Action Thérapeutique des gaz sous pression, IFR Jean Roche, Université de la Méditerranée, Faculté de Médecine Nord, Marseille Cedex, France.
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MeSH Terms
Blood Flow Velocity
Brachial Artery / ultrasonography
Hyperoxia / physiopathology*
Middle Aged
Oxygen Consumption / physiology*
Prospective Studies
Regional Blood Flow
Reproducibility of Results
Shock, Septic / physiopathology*,  therapy
Statistics, Nonparametric

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