Document Detail

Could heart rate play a role in pericardial inflammation?
MedLine Citation:
PMID:  22858356     Owner:  NLM     Status:  Publisher    
Purpose and medical hypothesis: Rest is usually recommended in acute pericarditis, as it could help to lower heart rate (HR) and contribute to limit "mechanical inflammation". Whether HR on admission could be correlated and perhaps participate to inflammation has not been reported. Methods: Between March 2007 and February 2010, we conducted a retrospective study on all patients admitted to our center for acute pericarditis. Diagnosis criteria included two of the following ones: typical chest pain, friction rub, pericardial effusion on cardiac echography, or typical electrocardiogram (ECG) findings. Primary endpoint was biology: CRP on admission, on days 1, 2, 3, and especially peak. Results: We included 73 patients. Median age was 38years (interquartiles 28-51) and median hospitalization duration was 2.0days (1.5-3.0). Median heart rate was 88.0beats per minute (bpm) on admission (interquartiles 76.0-100.0) and 72.0 on discharge (65.0-80.0). Heart rate on admission was significantly correlated with CRP peak (p<0.001), independently of temperature on admission, hospitalization duration and age. Recurrences occurred within 1month in 32% of patients. Heart rate on hospital discharge was correlated with recurrence, independently of age. Conclusion: In acute pericarditis, heart rate on admission is independently correlated with CRP levels and heart rate on discharge seems to be independently correlated to recurrence. This could suggest a link between heart rate and pericardial inflammation.
Ziad Khoueiry; Camille Roubille; Nicolas Nagot; Benoît Lattuca; Christophe Piot; Florence Leclercq; Delphine Delseny; David Busseuil; Richard Gervasoni; Jean-Marc Davy; Jean-Luc Pasquié; Frédéric Cransac; Catherine Sportouch-Dukhan; Jean-Christophe Macia; Thien-Tri Cung; François Massin; Stéphane Cade; Jean-Paul Cristol; Stéphanie Barrère-Lemaire; François Roubille
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-1
Journal Detail:
Title:  Medical hypotheses     Volume:  -     ISSN:  1532-2777     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Cardiology Department, University Hospital of Montpellier, Montpellier, France; Inserm, U1046, Universités de Montpellier 1 and 2, France.
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