| Could direct stenting reduce no-reflow in acute coronary syndromes? A randomized pilot study. | |
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MedLine Citation:
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PMID: 12075259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Recently, direct stenting has been shown in retrospective and randomized studies to be feasible and safe in highly selected patients, with a potential interest to reduce the cost of the procedure and the rate of no-reflow. This randomized pilot study was designed to compare the incidence of no-reflow after direct stenting or conventional stenting after balloon predilation in acute coronary syndrome-related lesions. METHODS AND RESULTS: Between December 1998 and October 1999, 130 patients in our center with acute coronary syndromes were included in this study and randomized in 2 groups. In group A (n = 65), direct stent implantation was performed without balloon predilation. In group B (n = 65), conventional balloon predilation was carried out before stent implantation. Baseline clinical and angiographic characteristics before the procedure were similar in the 2 groups of patients. No-reflow was observed in 7.7% after direct stenting and in 6.1% after conventional stent implantation (P = not significant). The immediate clinical success rate was similar in the 2 groups. Among the procedural data, only duration of the procedure (shorter in the direct stenting group), the number of balloons used, and the quantity of contrast agent (lower in the direct stenting group) were significantly different between the 2 groups (P <.05). The 6-month clinical outcome was similar in the 2 groups. CONCLUSION: This randomized study confirms the promising results of previous studies that show the feasibility and the safety of direct coronary stenting in highly selected acute coronary syndrome-related lesions. The major impact of this strategy is the improvement of the cost-benefit ratio, with no major influence on the acute complications and especially on the occurrence of no-reflow in this high-risk population. |
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Authors:
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Rémi Sabatier; Martial Hamon; Quan Ming Zhao; Francesco Burzotta; Emmanuel Lecluse; Benoit Valette; Gilles Grollier |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: American heart journal Volume: 143 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-06-20 Completed Date: 2002-07-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
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Languages: eng Pagination: 1027-32 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, University Hospital of Caen, Caen, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Aged Aged, 80 and over Angina, Unstable / therapy* Angioplasty, Transluminal, Percutaneous Coronary* / adverse effects, economics Coronary Angiography Coronary Circulation Feasibility Studies Female Humans Male Middle Aged Myocardial Infarction / therapy* Patient Selection Pilot Projects Safety Statistics as Topic Stents* / adverse effects, economics Syndrome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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