Document Detail

Could Malassezia yeasts be implicated in skin carcinogenesis through the production of aryl-hydrocarbon receptor ligands?
MedLine Citation:
PMID:  21444158     Owner:  NLM     Status:  MEDLINE    
HYPOTHESIS: Synthesis of available pertinent data show a possible link between Malassezia produced AhR ligands and skin carcinogenesis, particularly of basal cell carcinoma (BCC). BCCs are almost exclusively observed in animal species colonized by Malassezia. In humans and animals there is overlapping in the skin regions colonized by this yeast and affected by BCC. The potent AhR ligands synthesized by pathogenic Malassezia strains could contribute to tumor promotion by: modification of the UV radiation carcinogenesis, alterations in the salvage/survival of initiated tumor cells, inhibition of cell senescence, interaction with vitamin D metabolism, promotion of immune tolerance and finally pro-carcinogenic modulation of cell cycle progression and apoptosis.
G Gaitanis; A Velegraki; P Magiatis; P Pappas; I D Bassukas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-03-27
Journal Detail:
Title:  Medical hypotheses     Volume:  77     ISSN:  1532-2777     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-07     Completed Date:  2011-09-26     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  47-51     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Malassezia / pathogenicity*
Receptors, Aryl Hydrocarbon / metabolism*
Skin Neoplasms / microbiology*
Reg. No./Substance:
0/Ligands; 0/Receptors, Aryl Hydrocarbon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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