Document Detail


Could ADMA levels in young adults born preterm predict an early endothelial dysfunction?
MedLine Citation:
PMID:  21420186     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Sporadic data present in literature report how preterm birth and low birth weight are risk factors for the development of cardiovascular diseases in later life. High levels of asymmetric dimethylarginine (ADMA), a strong inhibitor of nitric oxide synthesis, are associated with the future development of adverse cardiovascular events and cardiac death.
AIMS: 1) to verify the presence of a statistically significant difference between ADMA levels in young adults born preterm at extremely low birth weight (<1000 g; ex-ELBW) and those of a control group of healthy adults born at term (C) and 2) to seek correlations between ADMA levels in ex-ELBW and anthropometric and clinical parameters (gender, chronological age, gestational age, birth weight, and duration of stay in Neonatal Intensive Care Unit).
METHODS: Thirty-two ex-ELBW subjects (11 males [M] and 21 females [F], aged 17-29years, mean age 22.2 ± 2.3 years) were compared with 25 C (7 M and 18F). ADMA levels were assessed by high-performance liquid chromatography with highly sensitive laser fluorescent detection.
RESULTS: ADMA levels were reduced in ex-ELBW subjects compared to C (0.606+0.095 vs 0.562+0.101 μmol/L, p<0.05), and significantly correlated inversely with gestational age (r=-0.61, p<0.00001) and birth weight (r=-0.57, p<0.0002).
CONCLUSIONS: Our findings reveal a significant decrease in ADMA levels of ex-ELBW subjects compared to C, underlining a probable correlation with preterm birth and low birth weight. Taken together, these results may underlie the onset of early circulatory dysfunction predictive of increased cardiovascular risk.
Authors:
P P Bassareo; M Puddu; G Flore; M Deidda; E Manconi; A Melis; V Fanos; G Mercuro
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Publication Detail:
Type:  Journal Article     Date:  2011-03-21
Journal Detail:
Title:  International journal of cardiology     Volume:  159     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-28     Completed Date:  2013-06-11     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  217-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Arginine / analogs & derivatives*,  blood
Early Diagnosis
Endothelium, Vascular / metabolism*,  physiopathology*
Female
Gestational Age
Humans
Infant, Extremely Low Birth Weight / blood
Infant, Low Birth Weight / blood*
Infant, Newborn
Male
Predictive Value of Tests
Premature Birth / blood,  epidemiology
Vascular Diseases / blood,  diagnosis*,  epidemiology
Young Adult
Chemical
Reg. No./Substance:
30315-93-6/N,N-dimethylarginine; 94ZLA3W45F/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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