Document Detail


Coughing induced by airway irritation modulates the sensation of air hunger.
MedLine Citation:
PMID:  17974590     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to clarify whether coughing elicited by airway irritation can modulate the sensation of air hunger. Using a visual analog scale (VAS), we measured air hunger for 30 s following breakpoint of a breath-hold in healthy young subjects who were asked to resume their breathing according to four patterns (free breathing, citric acid inhalation, voluntary cough, and panting) before and/or after airway anaesthesia. We also measured air hunger for citric acid-induced coughing and voluntary coughing without the preceding breath-holding. The free breathing after breakpoint of breath-holding causes an immediate relief of air hunger (VAS median values at 5, 15 and 25 s after breath-hold: 39, 0 and 0), whereas voluntary coughing causes a delay in the relief of air hunger (67, P < 0.05; 17, P < 0.05; and 0, NS) and a slower relief occurred during citric acid-induced coughing (81, P < 0.01; 49, P < 0.05; and 12, P < 0.05). Conversely, the voluntary coughing and citric acid-induced coughing per se failed to induce air hunger. Inhalation of lidocaine aerosol completely abolished the cough response to citric acid inhalation causing an immediate relief of air hunger, whereas airway anaesthesia alleviated only slightly the air hunger during voluntary coughing. The changes in air hunger during the panting were similar to those during the voluntary coughing observed before airway anaesthesia and were not affected by airway anaesthesia (VAS at 15 s point before versus after anaesthesia: 18 versus 15; NS). Coughing induced by airway irritation per se does not generate the sensation of air hunger but can aggravate it, presumably by vagally mediated mechanisms and/or central mechanisms.
Authors:
Takashi Nishino; Shiroh Isono; Norihiro Shinozuka; Teruhiko Ishikawa
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-01
Journal Detail:
Title:  The Journal of physiology     Volume:  586     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-14     Completed Date:  2008-04-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  649-58     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, Graduate School of Medicine, Chiba University, 1-8-1 Inohanacho, Chiba 260-8670, Japan. nishinot@faculty.chiba-u.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Anesthetics, Local / pharmacology
Citric Acid / pharmacology
Cough / physiopathology*
Female
Humans
Lidocaine / pharmacology
Male
Pain Measurement
Respiratory Mechanics / drug effects,  physiology*
Respiratory Physiological Phenomena / drug effects
Respiratory System / physiopathology*
Chemical
Reg. No./Substance:
0/Anesthetics, Local; 137-58-6/Lidocaine; 77-92-9/Citric Acid
Comments/Corrections

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