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Cough-reflex sensitivity to inhaled capsaicin in COPD associated with increased exacerbation frequency.
MedLine Citation:
PMID:  19761536     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: The causes of exacerbations in COPD patients are poorly understood. This study examined the association between cough-reflex sensitivity in patients with stable COPD and the frequency of subsequent exacerbations. METHODS: The sampling frame for cases and controls for this study was patients attending a hospital outpatient clinic. cough-reflex sensitivity was evaluated using the log concentration of capsaicin causing five or more coughs (log C(5)). Subsequent COPD exacerbations were identified prospectively via symptom-based diaries over a 12-month period. RESULTS: The study group comprised 45 COPD subjects and 10 controls. Mean log C(5) was lower in the COPD group than in the control group (0.97 (95% confidence interval (CI): 0.76-1.18) versus 1.26 (95% CI: 0.81-1.71), P = 0.095). In the COPD group, log C(5) was negatively correlated with serum CRP level (r = -0.36, P = 0.02) and significantly associated with the exacerbation frequency (r = -0.38, P = 0.01). Stepwise multiple regression analysis showed that cough-reflex sensitivity was significantly associated with exacerbation frequency (r(2) = 0.15, P = 0.01). CONCLUSIONS: Hypersensitivity of the cough reflex to inhaled capsaicin might reflect airway inflammation in stable COPD patients, which predisposes to frequent exacerbations.
Authors:
Kunihiko Terada; Shigeo Muro; Tadashi Ohara; Akane Haruna; Satoshi Marumo; Megumi Kudo; Emiko Ogawa; Yuma Hoshino; Toyohiro Hirai; Akio Niimi; Michiaki Mishima
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Publication Detail:
Type:  Journal Article     Date:  2009-09-16
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  14     ISSN:  1440-1843     ISO Abbreviation:  Respirology     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1151-5     Citation Subset:  IM    
Affiliation:
Department of Respiratory Medicine, Kyoto University, Kyoto 606-8507, Japan.
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