| Cough-reflex sensitivity to inhaled capsaicin in COPD associated with increased exacerbation frequency. | |
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MedLine Citation:
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PMID: 19761536 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: The causes of exacerbations in COPD patients are poorly understood. This study examined the association between cough-reflex sensitivity in patients with stable COPD and the frequency of subsequent exacerbations. METHODS: The sampling frame for cases and controls for this study was patients attending a hospital outpatient clinic. cough-reflex sensitivity was evaluated using the log concentration of capsaicin causing five or more coughs (log C(5)). Subsequent COPD exacerbations were identified prospectively via symptom-based diaries over a 12-month period. RESULTS: The study group comprised 45 COPD subjects and 10 controls. Mean log C(5) was lower in the COPD group than in the control group (0.97 (95% confidence interval (CI): 0.76-1.18) versus 1.26 (95% CI: 0.81-1.71), P = 0.095). In the COPD group, log C(5) was negatively correlated with serum CRP level (r = -0.36, P = 0.02) and significantly associated with the exacerbation frequency (r = -0.38, P = 0.01). Stepwise multiple regression analysis showed that cough-reflex sensitivity was significantly associated with exacerbation frequency (r(2) = 0.15, P = 0.01). CONCLUSIONS: Hypersensitivity of the cough reflex to inhaled capsaicin might reflect airway inflammation in stable COPD patients, which predisposes to frequent exacerbations. |
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Authors:
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Kunihiko Terada; Shigeo Muro; Tadashi Ohara; Akane Haruna; Satoshi Marumo; Megumi Kudo; Emiko Ogawa; Yuma Hoshino; Toyohiro Hirai; Akio Niimi; Michiaki Mishima |
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Publication Detail:
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Type: Journal Article Date: 2009-09-16 |
Journal Detail:
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Title: Respirology (Carlton, Vic.) Volume: 14 ISSN: 1440-1843 ISO Abbreviation: Respirology Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9616368 Medline TA: Respirology Country: Australia |
Other Details:
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Languages: eng Pagination: 1151-5 Citation Subset: IM |
Affiliation:
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Department of Respiratory Medicine, Kyoto University, Kyoto 606-8507, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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