| The cough hypersensitivity syndrome: a novel paradigm for understanding cough. | |
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MedLine Citation:
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PMID: 19809853 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For many years patients with chronic cough have been investigated in an attempt to diagnose the cause of the cough. Here I suggest that the overwhelming majority of patients with chronic cough have a single diagnosis: cough hypersensitivity syndrome. This is demonstrated by the homogeneous nature of the clinical history and investigational results of patients attending cough clinics. The hypersensitivity facet of the syndrome is demonstrated by objective testing with capsaicin and other protussive agents. Within the cough hypersensitivity syndrome there are different phenotypes. Those patients with a predominantly Th2-type immune response will develop eosinophilic inflammation and either cough-variant asthma or eosinophilic bronchitis. Those with predominantly heartburn symptoms will have a phenotype that reflects GERD and cough. However, the similarities between the different phenotypes far outweigh differences in a unifying diagnosis of the cough hypersensitivity syndrome, providing a more rational understanding of chronic cough. |
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Authors:
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Alyn H Morice |
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Publication Detail:
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Type: Journal Article Date: 2009-10-07 |
Journal Detail:
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Title: Lung Volume: 188 Suppl 1 ISSN: 1432-1750 ISO Abbreviation: Lung Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-04 Completed Date: 2010-07-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7701875 Medline TA: Lung Country: United States |
Other Details:
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Languages: eng Pagination: S87-90 Citation Subset: IM |
Affiliation:
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Cardiovascular and Respiratory Studies, Hull York Medical School, Castle Hill Hospital, University of Hull, Cottingham, East Yorkshire, HU16 5JQ, UK, a.h.morice@hull.ac.uk. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Asthma
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complications,
physiopathology Bronchitis / complications Capsaicin Chronic Disease Cough / chemically induced, etiology*, immunology Gastroesophageal Reflux / complications Humans Hypersensitivity / complications*, physiopathology Irritants Nasal Mucosa / secretion Pulmonary Disease, Chronic Obstructive / complications Pulmonary Eosinophilia / complications Syndrome TRPV Cation Channels / physiology |
| Chemical | |
Reg. No./Substance:
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0/Irritants; 0/TRPV Cation Channels; 0/TRPV1 protein, human; 404-86-4/Capsaicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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