Document Detail


Cotyledonary responses to maternal selenium and dietary restriction may influence alterations in fetal weight and fetal liver glycogen in sheep.
MedLine Citation:
PMID:  19501989     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
To examine the effects of maternal supranutritional selenium (Se) and nutrient restriction during mid and late gestation on placental characteristics and fetal liver glycogen, ewes received either adequate Se (ASe) or high Se (HSe) prior to breeding. On d 64 of gestation, ASe and HSe ewes remained at 100% of requirements (controls; CON) or were restricted (RES; 60% of requirements). On d 135 of gestation, fetal weight (P< or =0.08) was greatest in both HSe and CON ewes. Placentome number, mass, and caruncular and cotyledonary weight were not different (P> or =0.17) among treatments. Fetal mass:placental mass ratio was less (P=0.06) in RES compared to CON ewes. Compared to ASe, HSe exhibited increased (P< or =0.08) cellular proliferation and DNA concentration and decreased (P=0.07) cellular size in cotyledonary tissue. Nutritional restriction decreased (P< or =0.08) cotyledonary protein concentration and cellular size. VEGF receptor 1 (Flt) mRNA in cotyledonary tissue was greater in HSe compared with ASe ewes (P=0.06) and in RES compared with CON ewes (P=0.08). There was no effect of diet on caruncular growth variables (P> or =0.13) or on placental vascularity (P> or =0.11). Progesterone was greater (P< or =0.08) in ASe-RES ewes compared to all groups at d 90 and ASe-CON and HSe-CON at d 104. Although fetal glucose and cortisol concentrations were not affected by diet, fetal liver glycogen was greater (P=0.04) in ASe-RES compared to ASe-CON and HSe-RES ewes with HSe-CON being intermediate. Both Se and nutritional plane may impact placental function and fetal growth, as fetal weight and liver glycogen are altered despite similar placental vascularity measurements.
Authors:
L A Lekatz; M A Ward; P P Borowicz; J B Taylor; D A Redmer; A T Grazul-Bilska; L P Reynolds; J S Caton; K A Vonnahme
Related Documents :
12766649 - Fetal plasma concentrations after intraamniotic sufentanil in chronically instrumented ...
15961559 - Maternal nutritional programming of fetal adipose tissue development: differential effe...
8627939 - Pregnancy detection in bighorn sheep (ovis canadensis) using a fecal-based enzyme immun...
7431239 - Delayed development of amiloride-sensitive sodium transport in lamb distal colon.
8977439 - Pregnancy induces an increase in angiotensin ii type-1 receptor expression in uterine b...
5387729 - Toxemia of pregnancy in sheep: a clinical, physiological, and pathological study.
8864429 - Fetal mouse lung ultrastructural maturation is accelerated by maternal thyrotropin-rele...
11750959 - The perinatal outcome of pregnancy without prenatal care. a retrospective study in szeg...
9572449 - Bilateral simultaneous tubal sextuplets: pregnancy after in-vitro fertilization--embryo...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2009-05-18
Journal Detail:
Title:  Animal reproduction science     Volume:  117     ISSN:  1873-2232     ISO Abbreviation:  Anim. Reprod. Sci.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2009-11-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7807205     Medline TA:  Anim Reprod Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  216-25     Citation Subset:  IM    
Affiliation:
Center for Nutrition and Pregnancy, Department of Animal Sciences, North Dakota State University, Fargo, United States.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
HL 64141/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Digital slides: present status of a tool for consultation, teaching, and quality control in patholog...
Next Document:  Development of the ovary and ontongeny of mRNA and protein for P450 aromatase (arom) and estrogen re...