Document Detail


Cotinine levels in relation to smoking behavior and addiction in young adolescent smokers.
MedLine Citation:
PMID:  17365743     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The goal of this study was to identify associations among self-reported nicotine exposure, nicotine addiction, and actual nicotine intake as measured by salivary cotinine levels in adolescent smokers. A total of 170 adolescent smokers with a mean age of 15 years were recruited from seven northern Californian public high schools. Data were collected on smoking behaviors, addiction, craving, and withdrawal. Nicotine dependence was assessed using a modified teen Fagerström Tolerance Questionnaire (mtFTQ), a modified Nicotine Dependence Syndrome Scale (mNDSS), and a simple self-rating. Withdrawal was assessed using the Minnesota Withdrawal Questionnaire, and craving was assessed using a survey created by the authors. Salivary cotinine levels were collected from and analysed in participants who self-identified as smokers; data from the 54 participants who smoked in the past 4 days and whose salivary cotinine levels were greater than 0.1 ng/ml were used in the analysis. Among this group of adolescent smokers, the mean number of cigarettes smoked per day was 3.51 (SD = 3.44) and the mean level of salivary cotinine was 44.1 ng/ml (Mdn = 24.2). Even at this low level of nicotine exposure, cotinine was highly correlated with measures of nicotine dependence such as the mtFTQ (r = 0.497, p = .001), NDSS (r = 0.439, p = .002), timing of craving in the morning (r = -0.601, p = .000), and self-rated addiction (r = 0.562, p = .000). Most interesting, cotinine levels reached a plateau at around 4-5 cigarettes/day.
Authors:
Mark L Rubinstein; Pamela J Thompson; Neal L Benowitz; Saul Shiffman; Anna-Barbara Moscicki
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco     Volume:  9     ISSN:  1462-2203     ISO Abbreviation:  Nicotine Tob. Res.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-03-16     Completed Date:  2007-05-08     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  9815751     Medline TA:  Nicotine Tob Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  129-35     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Behavior, Addictive / epidemiology*
Cotinine / analysis*
Female
Humans
Male
Questionnaires
Saliva / chemistry
Smoking / blood*,  epidemiology*
Smoking Cessation / methods
Grant Support
ID/Acronym/Agency:
DA01393/DA/NIDA NIH HHS; DA02277/DA/NIDA NIH HHS; K23 RR018471/RR/NCRR NIH HHS; K23 RR018471-02/RR/NCRR NIH HHS; K23 RR018471-05/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
K5161X06LL/Cotinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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