Document Detail

Cosupplementation of isoflavones, prenylflavonoids, and lignans alters human exposure to phytoestrogen-derived 17beta-estradiol equivalents.
MedLine Citation:
PMID:  19864398     Owner:  NLM     Status:  MEDLINE    
The microbial metabolism of dietary phytoestrogens varies considerably among individuals and influences the final exposure to bioactive compounds. In view of the increasing number of food supplements combining several classes of phytoestrogens, the microbial potential to activate various proestrogens within an individual was evaluated in 3 randomized dietary crossovers. Treatment allocation was based on participants' eligibility (>45% in vitro bioactivation of >or=2 separate proestrogens by fecal cultures; n = 40/100). After a run-in of >or=4 d, participants were given soy-, hop-, and/or flax-based food supplements dosed either separately (SOY: 2.83 mg daidzein aglycone equivalents/supplement, HOP: 1.20 mg isoxanthohumol (IX)/supplement, or FLAX: 2.08 mg secoisolariciresinol (SECO) aglycone equivalents/supplement; reference intervention) or simultaneously (MIX; test intervention) 3 times/d for 5 d, followed by a wash-out period (>or=7 d) and the second intervention. Before and after each (co)supplementation, spot urine and serum were collected. In total, 22 equol, 19 8-prenylnaringenin (8-PN), and 21 enterolactone (ENL) producers completed the SOY+MIX, HOP+MIX, and FLAX+MIX trials, respectively. The microbial bioactivation of daidzein, IX, and SECO, generally decreased upon coincubation in vitro (equol: 4.4%, P = 0.164; 8-PN: 20.5%, P < 0.001; ENL: 44.3%, P < 0.001) and cosupplementation in vivo (equol: 28.3%, P = 0.009; 8-PN: 35.4%, P = 0.107; ENL: 35.9%, P = 0.003). Although the bioavailabilities of total isoflavones, prenylflavonoids, and lignans were not significantly affected upon coadministration, participants were exposed to lower phytoestrogen-derived 17beta-estradiol equivalents. In conclusion, the bioavailability of phytoestrogens, especially when given in mixtures, is subject to high interindividual variation. These findings support the importance of personalized screening when assessing the efficacy of such products and mixtures.
Selin Bolca; Ciska Wyns; Sam Possemiers; Herman Depypere; Denis De Keukeleire; Marc Bracke; Willy Verstraete; Arne Heyerick
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-28
Journal Detail:
Title:  The Journal of nutrition     Volume:  139     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-25     Completed Date:  2010-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2293-300     Citation Subset:  IM    
Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.
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MeSH Terms
Dietary Supplements*
Estradiol / analogs & derivatives*,  analysis,  pharmacology
Feces / chemistry
Flavanones / analysis
Flavonoids / pharmacology*
Genistein / pharmacology
Isoflavones / analysis,  pharmacology*
Lignans / pharmacology*
Phytoestrogens / pharmacology*
Reg. No./Substance:
0/8-prenylnaringenin; 0/Flavanones; 0/Flavonoids; 0/Isoflavones; 0/Lignans; 0/Phytoestrogens; 0/dihydrodaidzein; 446-72-0/Genistein; 486-66-8/daidzein; 50-28-2/Estradiol; 531-95-3/equol; 76543-16-3/2,3-bis(3'-hydroxybenzyl)butane-1,4-diol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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