Document Detail


Costs of resistance: genetic correlations and potential trade-offs in an insect immune system.
MedLine Citation:
PMID:  15009275     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Theory predicts that natural selection will erode additive genetic variation in fitness-related traits. However, numerous studies have found considerable heritable variation in traits related to immune function, which should be closely linked to fitness. This could be due to trade-offs maintaining variation in these traits. We used the Egyptian cotton leafworm, Spodoptera littoralis, as a model system to examine the quantitative genetics of insect immune function. We estimated the heritabilities of several different measures of innate immunity and the genetic correlations between these immune traits and a number of life history traits. Our results provide the first evidence for a potential genetic trade-off within the insect immune system, with antibacterial activity (lysozyme-like) exhibiting a significant negative genetic correlation with haemocyte density, which itself is positively genetically correlated with both haemolymph phenoloxidase activity and cuticular melanization. We speculate on a potential trade-off between defence against parasites and predators, mediated by larval colour, and its role in maintaining genetic variation in traits under natural selection.
Authors:
S C Cotter; L E B Kruuk; K Wilson
Related Documents :
14960765 - Numerical method for detection of linkage between genes for two metrical traits.
17898985 - Qtl analysis reveals context-dependent loci for seed glucosinolate trait in the oilseed...
6539325 - Reproductive performance in a diallel cross among lines of mice selected for litter siz...
20394605 - Indirect effect of igf2 intron3 g.3072g>a mutation on prolificacy in sows.
2113845 - Different requirements for l(1) giant in two embryonic domains of drosophila melanogaster.
11112665 - Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased ...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of evolutionary biology     Volume:  17     ISSN:  1010-061X     ISO Abbreviation:  J. Evol. Biol.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-10     Completed Date:  2004-10-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8809954     Medline TA:  J Evol Biol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  421-9     Citation Subset:  IM    
Affiliation:
Institute of Biological Sciences, University of Stirling, Stirling, UK. sheena.cotter@csiro.au
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Anti-Infective Agents / immunology
Blood Cell Count
Body Weight
Genetic Variation*
Larva / growth & development,  immunology
Likelihood Functions
Longevity
Melanins / metabolism
Monophenol Monooxygenase / blood
Muramidase / immunology
Population Density
Quantitative Trait, Heritable
Selection, Genetic*
Spodoptera / genetics,  growth & development,  immunology*
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Melanins; EC 1.14.18.1/Monophenol Monooxygenase; EC 3.2.1.17/Muramidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The relationship between morphology, escape behaviour and microhabitat occupation in the lizard clad...
Next Document:  Molecular, morphological and behavioural data reveal the presence of a cryptic species in the widely...