Document Detail


Cost-effectiveness of various methods of diagnosing hypersensitivity to Alternaria.
MedLine Citation:
PMID:  8237720     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was undertaken for two reasons: 1) It is more difficult to diagnose hypersensitivity to molds than to other allergens, so an evaluation of diagnostic tests was needed. 2) Alternaria is the principal cause of mold sensitization in our area. Sixty-six patients (20 +/- 4 years) were selected and divided into two groups. Group A was made up of patients with rhinitis and/or asthma due to Alternaria sensitization. Group B consisted of patients sensitized to other allergens and patients with nonrespiratory allergic disorders. Skin tests (prick and intradermal), challenge tests (conjunctival, nasal, and bronchial), and specific IgE determination were performed for all patients. A biologically standardized extract of Alternaria tenuis (Alergia e Inmunología Abelló, S. A., Madrid, Spain) obtained from a single batch was used for all tests. Our diagnostic criterion was a clinical history of rhinitis or asthma that coincided with the results of nasal/bronchial challenge. The diagnostic value of the other tests was compared to this criterion. In the group of rhinitic patients, skin tests and conjunctival challenge were more sensitive than specific IgE determination. In asthmatic patients, the most sensitive techniques were nasal and conjunctival challenges, followed by prick and intradermal skin tests, and, lastly, serum specific IgE determination. When rhinitis and asthma were considered jointly, the most sensitive test was conjunctival challenge, followed by skin-prick and intradermal tests. All tests had the same specificity, regardless of disorder. Nasal challenge was positive in all patients. Skin tests are easy to perform, cheap, non-traumatic for the patient, and sufficiently specific and sensitive for the diagnosis of Alternaria hypersensitivity.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
A I Escudero; I M Sánchez-Guerrero; A M Mora; V Soriano; J D López; F J García; J M Negro; J Hernández; J A Pagán
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Allergologia et immunopathologia     Volume:  21     ISSN:  0301-0546     ISO Abbreviation:  Allergol Immunopathol (Madr)     Publication Date:    1993 Jul-Aug
Date Detail:
Created Date:  1993-12-21     Completed Date:  1993-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370073     Medline TA:  Allergol Immunopathol (Madr)     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  153-7     Citation Subset:  IM    
Affiliation:
Allergy Section, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Alternaria / immunology*
Asthma / diagnosis*,  etiology
Bronchial Provocation Tests / economics
Child
Child, Preschool
Conjunctivitis, Allergic / etiology
Cost-Benefit Analysis
Enzyme-Linked Immunosorbent Assay / economics
Female
Humans
Immunologic Tests / economics*
Male
Middle Aged
Nasal Provocation Tests / economics
Plant Extracts
Radioallergosorbent Test / economics
Rhinitis, Allergic, Perennial / diagnosis*,  etiology
Sensitivity and Specificity
Skin Tests / economics
Chemical
Reg. No./Substance:
0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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