Document Detail


Cost-effectiveness of spironolactone in patients with severe heart failure.
MedLine Citation:
PMID:  12930056     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Management of heart failure is estimated to consume between 1% and 2% of total healthcare resources with hospital admissions accounting for up to 70% of this. The ability of the aldosterone antagonist spironolactone to reduce hospital admission rates by 35% would be expected to prove cost-effective. AIM: To determine the cost-effectiveness of spironolactone when added to standard therapy in patients with severe chronic heart failure. METHODS: A Markov model of chronic heart failure was constructed using Treeage software. Irish cost data were incorporated into the model. RESULTS: The incremental cost-effectiveness ratio (ICER) for spironolactone therapy was Euro 466 per life year gained (LYG). Sensitivity analysis demonstrated an ICER range of Euro 75 to Euro 1,136 per LYG. CONCLUSION: This economic evaluation suggests that the addition of spironolactone to standard therapy for patients with severe chronic heart failure is not only safe and effective, but is highly cost-effective in the Irish healthcare setting.
Authors:
L Tilson; B McGowan; M Ryan; M Barry
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Irish journal of medical science     Volume:  172     ISSN:  0021-1265     ISO Abbreviation:  Ir J Med Sci     Publication Date:    2003 Apr-Jun
Date Detail:
Created Date:  2003-08-21     Completed Date:  2003-12-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7806864     Medline TA:  Ir J Med Sci     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  70-2     Citation Subset:  IM    
Affiliation:
National Centre for Pharmacoeconomics, St James's Hospital, Dublin, Ireland.
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MeSH Terms
Descriptor/Qualifier:
Aldosterone Antagonists / economics*,  therapeutic use*
Cost-Benefit Analysis
Costs and Cost Analysis
Heart Failure / drug therapy*
Humans
Markov Chains
Spironolactone / economics*,  therapeutic use*
Chemical
Reg. No./Substance:
0/Aldosterone Antagonists; 52-01-7/Spironolactone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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