| Cost-effectiveness of saxagliptin (Onglyza(®)) in type 2 diabetes in Sweden. | |
| | |
MedLine Citation:
|
PMID: 22001114 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
AIM: The objective of this study was to investigate the cost-effectiveness of saxagliptin (Onglyza(®)), a DPP-4 inhibitor, plus metformin compared with a sulphonylurea (SU) (Glipizide) plus metformin in Swedish patients not well controlled on metformin alone. METHODS: Data from a 52-week clinical trial comparing saxagliptin and glipizide in combination with metformin was used in a simulation model to estimate long term complications in a cohort of type 2 diabetes patients. The model estimates the incidence of microvascular and macrovascular complications, diabetes-specific mortality, all-cause mortality, and ultimately, costs and quality-adjusted life years (QALYs) associated with the investigated treatment strategies. Costs and QALYs were estimated for a lifetime time horizon. RESULTS: Compared with SU+metformin, the cost per QALY gained with saxagliptin+metformin is approximately SEK 91,000. Patients on saxagliptin+metformin gain 0.10 QALYs on average, at an incremental cost of around SEK 9500. The cost-effectiveness results were robust to various sensitivity analyses. CONCLUSIONS: This study demonstrates that, over a patient's lifetime, the addition of saxagliptin to metformin is associated with improvements in quality-adjusted life years compared with SU in patients with type 2 diabetes. Saxagliptin treatment is a cost-effective treatment alternative for type 2 diabetes in patients not well-controlled on metformin alone. |
| | |
Authors:
|
Ola Granström; Klas Bergenheim; Phil McEwan; Karin Sennfält; Martin Henriksson |
Related Documents
:
|
2040644 - Motility of bile canaliculi in the living animal: implications for bile flow. 16389454 - Liver x receptors in cardiovascular and metabolic disease. 16581304 - Hexokinase and glucose-6-phosphatase activity in woodchuck model of hepatitis virus-ind... 14701664 - Streptozotocin-induced diabetes impairs mg2+ homeostasis and uptake in rat liver cells. 15955844 - Leptin pulsatility in formerly obese women. 1742694 - Non-insulin-dependent (type ii) diabetes mellitus. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-14 |
Journal Detail:
|
Title: Primary care diabetes Volume: - ISSN: 1751-9918 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101463825 Medline TA: Prim Care Diabetes Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
|
AstraZeneca, Södertälje, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hemogenic endothelium: Origins, regulation, and implications for vascular biology.
Next Document: FoxA1 and glucocorticoid receptor crosstalk via histone H4K16 acetylation at a hormone regulated enh...