| Cost-effectiveness of positron emission tomography for non-small cell lung carcinoma in Canada. | |
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MedLine Citation:
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PMID: 15114279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Several studies over the past decade have demonstrated that 2-fluoro-2-D-[18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) is more accurate than computed tomography (CT) for the staging of non-small cell lung carcinoma (NSCLC). This study uses quantitative decision tree modeling and sensitivity analysis to assess the cost-effectiveness of both a CT- and a CT+PET-based management strategy for staging NSCLC in Canada. Both management costs and life expectancy are determined. MATERIAL/METHODS: Two patient management scenarios were compared--one using CT alone and one using both CT and PET. A survey of recent literature was used to construct a meta-analysis of available studies for the accuracies of CT and PET in staging NSCLC. Life expectancies were determined from recent Canadian statistics, and expected life expectancies with disease were calculated from knowledge of published survival rates. Management costs were determined from: estimates of the installation cost of PET facilities in Canada; management costs from our institutions; and recently published Canadian cost estimates of various procedures. RESULTS: A cost savings of 1455 Canadian dollars per person is expected for the CT+PET strategy, along with an increase in life expectancy (3.1 days), when compared with the CT alone strategy. This cost savings remained in favour of the CT+PET strategy when subjected to a rigorous sensitivity analysis. CONCLUSIONS: PET may be a cost effective means of staging NSCLC in Canada. |
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Authors:
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J Scott Sloka; Peter Darroch Hollett; Maria Mathews |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2004-04-28 |
Journal Detail:
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Title: Medical science monitor : international medical journal of experimental and clinical research Volume: 10 ISSN: 1234-1010 ISO Abbreviation: Med. Sci. Monit. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-05-05 Completed Date: 2004-07-02 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 9609063 Medline TA: Med Sci Monit Country: Poland |
Other Details:
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Languages: eng Pagination: MT73-80 Citation Subset: IM |
Affiliation:
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Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada. p97jss@mun.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Non-Small-Cell Lung
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diagnosis* Decision Trees Humans Lung Neoplasms / diagnosis* Neoplasm Staging / methods* Sensitivity and Specificity Tomography, Emission-Computed / economics* |
| Comments/Corrections | |
Comment In:
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Med Sci Monit. 2004 Jul;10(7):LE9-11
[PMID:
15232512
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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