Document Detail


Cost-effectiveness of exercise therapy in patients with intermittent claudication: supervised exercise therapy versus a 'go home and walk' advice.
MedLine Citation:
PMID:  21159527     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVES: The Exercise Therapy in Peripheral Arterial Disease (EXITPAD) study has shown supervised exercise therapy (SET) to be more effective regarding walking distance and quality of life than a 'go home and walk' advice (WA) for patients with intermittent claudication. The present study aims to assess the cost-effectiveness of SET versus WA.
PATIENTS AND METHODS: Data from the EXITPAD study, a 12-month randomised controlled trial in 304 patients with claudication, was used to study the proportion of costs to walking distance and quality of life. Two different incremental cost-effectiveness ratios (ICERs) were calculated for SET versus WA: costs per extra metre on the treadmill test, and costs per quality-adjusted life year (QALY). QALYs were based on utilities derived from the EuroQoL-5 dimensions (EQ-5D).
RESULTS: Mean total costs were higher for SET than for WA (3407 versus 2304 Euros), mainly caused by the costs of exercise therapy. The median walking distance was 620 m for SET and 400 m for WA. QALYs were 0.71 for SET and 0.67 for WA. All differences were statistically significant. The ICER for cost per extra metre on the 12-month treadmill test was € 4.08. For cost per QALY, the ICER was € 28,693.
CONCLUSION: At a willingness-to-pay threshold of € 40,000 per QALY, SET likely is a cost-effective therapeutic option for patients with claudication.
Authors:
A D I van Asselt; S P A Nicolaï; M A Joore; M H Prins; J A W Teijink;
Related Documents :
24669787 - Perceived variety, psychological needs satisfaction, and exercise-related well-being.
16375627 - The role of erythropoietin in myocardial protection: potential mechanisms and applicati...
19488067 - Cardiovascular and metabolic complications during androgen deprivation: exercise as a p...
9276167 - Loss of cardiovascular adaptations after physical inactivity.
19207717 - Effect of exercise on glutamine synthesis and transport in skeletal muscle from rats.
12172607 - The influence of bark on the fermentation of douglas-fir whitewood pre-hydrolysates.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-14
Journal Detail:
Title:  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     Volume:  41     ISSN:  1532-2165     ISO Abbreviation:  Eur J Vasc Endovasc Surg     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9512728     Medline TA:  Eur J Vasc Endovasc Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  97-103     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Maastricht University Medical Center, Department of Clinical Epidemiology and Medical Technology Assessment, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Investigator
Investigator/Affiliation:
A D I van Asselt / ; Saskia P A Nicolaï / ; Manuela A Joore / ; Edith M Willigendael / ; Bianca L W Bendermacher / ; Lotte M Kruidenier / ; Rob J van Det / ; Paul J G Jörning / ; Anco Vahl / ; Rudolph P Tutein Nolthenius / ; Philippe W M Cuypers / ; Marie-Louise E L Bartelink / ; Erik J M Hendriks / ; Rob A de Bie / ; Martin H Prins / ; Joep A W Teijink /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Comparison of the retention rates between carbamazepine and valproate as an initial monotherapy in C...
Next Document:  Chronic Homocysteine Exposure Upregulates Endothelial Adhesion Molecules and Mediates Leukocyte: End...