Document Detail

Cost-effectiveness of exercise therapy in patients with intermittent claudication: supervised exercise therapy versus a 'go home and walk' advice.
MedLine Citation:
PMID:  21159527     Owner:  NLM     Status:  In-Process    
OBJECTIVES: The Exercise Therapy in Peripheral Arterial Disease (EXITPAD) study has shown supervised exercise therapy (SET) to be more effective regarding walking distance and quality of life than a 'go home and walk' advice (WA) for patients with intermittent claudication. The present study aims to assess the cost-effectiveness of SET versus WA.
PATIENTS AND METHODS: Data from the EXITPAD study, a 12-month randomised controlled trial in 304 patients with claudication, was used to study the proportion of costs to walking distance and quality of life. Two different incremental cost-effectiveness ratios (ICERs) were calculated for SET versus WA: costs per extra metre on the treadmill test, and costs per quality-adjusted life year (QALY). QALYs were based on utilities derived from the EuroQoL-5 dimensions (EQ-5D).
RESULTS: Mean total costs were higher for SET than for WA (3407 versus 2304 Euros), mainly caused by the costs of exercise therapy. The median walking distance was 620 m for SET and 400 m for WA. QALYs were 0.71 for SET and 0.67 for WA. All differences were statistically significant. The ICER for cost per extra metre on the 12-month treadmill test was € 4.08. For cost per QALY, the ICER was € 28,693.
CONCLUSION: At a willingness-to-pay threshold of € 40,000 per QALY, SET likely is a cost-effective therapeutic option for patients with claudication.
A D I van Asselt; S P A Nicolaï; M A Joore; M H Prins; J A W Teijink;
Related Documents :
24669787 - Perceived variety, psychological needs satisfaction, and exercise-related well-being.
16375627 - The role of erythropoietin in myocardial protection: potential mechanisms and applicati...
19488067 - Cardiovascular and metabolic complications during androgen deprivation: exercise as a p...
24787677 - A methodological approach to quantifying plyometric intensity.
19207717 - Effect of exercise on glutamine synthesis and transport in skeletal muscle from rats.
12172607 - The influence of bark on the fermentation of douglas-fir whitewood pre-hydrolysates.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-14
Journal Detail:
Title:  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     Volume:  41     ISSN:  1532-2165     ISO Abbreviation:  Eur J Vasc Endovasc Surg     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9512728     Medline TA:  Eur J Vasc Endovasc Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  97-103     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
Maastricht University Medical Center, Department of Clinical Epidemiology and Medical Technology Assessment, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
A D I van Asselt / ; Saskia P A Nicolaï / ; Manuela A Joore / ; Edith M Willigendael / ; Bianca L W Bendermacher / ; Lotte M Kruidenier / ; Rob J van Det / ; Paul J G Jörning / ; Anco Vahl / ; Rudolph P Tutein Nolthenius / ; Philippe W M Cuypers / ; Marie-Louise E L Bartelink / ; Erik J M Hendriks / ; Rob A de Bie / ; Martin H Prins / ; Joep A W Teijink /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparison of the retention rates between carbamazepine and valproate as an initial monotherapy in C...
Next Document:  Chronic Homocysteine Exposure Upregulates Endothelial Adhesion Molecules and Mediates Leukocyte: End...