Document Detail

Cost-effectiveness of cytogenetic evaluation of products of conception in the patient with a second pregnancy loss.
MedLine Citation:
PMID:  22748232     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: To compare the cost of two strategies for managing the patient with recurrent pregnancy loss (RPL).
DESIGN: Cost analysis using a decision analytic model was used to compare obtaining an evidence-based workup (EBW) for RPL versus obtaining a karyotype of the products of conception (POC) and proceeding with an EBW only in the setting of euploid POC.
SETTING: Outpatient care.
PATIENT(S): A simulated cohort of patients experiencing a second pregnancy loss.
INTERVENTION(S): Not applicable.
MAIN OUTCOME MEASURE(S): Total cost of investigating the cause of RPL after a second pregnancy loss.
RESULT(S): For all age categories, obtaining a karyotype of POC was less costly than an evidenced-based RPL evaluation. Monte Caro analysis demonstrated a net economic benefit for the karyotype strategy ($4,498 [±$792] vs. $5,022 [±$1,130]).
CONCLUSION(S): Our model suggests an economic advantage for obtaining a karyotype of POC in women with second miscarriage.
Nastaran Foyouzi; Marcelle I Cedars; Heather G Huddleston
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  98     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  151-155.e3     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, UCSF Center for Reproductive Health, San Francisco, California.
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