Document Detail


Cost-effectiveness of cytogenetic evaluation of products of conception in the patient with a second pregnancy loss.
MedLine Citation:
PMID:  22748232     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: To compare the cost of two strategies for managing the patient with recurrent pregnancy loss (RPL).
DESIGN: Cost analysis using a decision analytic model was used to compare obtaining an evidence-based workup (EBW) for RPL versus obtaining a karyotype of the products of conception (POC) and proceeding with an EBW only in the setting of euploid POC.
SETTING: Outpatient care.
PATIENT(S): A simulated cohort of patients experiencing a second pregnancy loss.
INTERVENTION(S): Not applicable.
MAIN OUTCOME MEASURE(S): Total cost of investigating the cause of RPL after a second pregnancy loss.
RESULT(S): For all age categories, obtaining a karyotype of POC was less costly than an evidenced-based RPL evaluation. Monte Caro analysis demonstrated a net economic benefit for the karyotype strategy ($4,498 [±$792] vs. $5,022 [±$1,130]).
CONCLUSION(S): Our model suggests an economic advantage for obtaining a karyotype of POC in women with second miscarriage.
Authors:
Nastaran Foyouzi; Marcelle I Cedars; Heather G Huddleston
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  98     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  151-155.e3     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, UCSF Center for Reproductive Health, San Francisco, California.
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