Document Detail

Cost-effective diagnosis of deep vein thrombosis and pulmonary embolism.
MedLine Citation:
PMID:  11487038     Owner:  NLM     Status:  MEDLINE    
Suspected acute venous thromboembolism is a frequent and challenging clinical problem. Phlebography and pulmonary angiography are costly and invasive and, hence, ill-suited for diagnosing a disease present in only 20% of patients in whom it is suspected. Novel noninvasive instruments, such as plasma D-dimer measurement, lower limb compression ultrasonography and helical CT scan are important breakthroughs in the management of patients with suspected venous thromboembolism. However, none of these instruments is ideal, and they must be combined in rational and cost-effective diagnostic algorithms including clinical assessment, which is increasingly standardized. Such strategies must be validated in management studies, in which patients without venous thromboembolism are not treated and followed up during 3 months. Suspected massive pulmonary embolism is a distinct clinical situation requiring a specific diagnostic approach, in which echocardiography plays a major role. This paper reviews the performance of clinical evaluation and diagnostic tests for venous thromboembolism, and recently validated diagnostic schemes.
A Perrier; H Bounameaux
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  86     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-08-06     Completed Date:  2002-01-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  475-87     Citation Subset:  IM    
Medical Clinic 1, Department of Internal Medicine, Geneva University Hospital, Switzerland.
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MeSH Terms
Cost-Benefit Analysis
Diagnostic Imaging / economics,  standards
Electrocardiography / economics,  standards
Pulmonary Embolism / diagnosis*,  economics
Reagent Kits, Diagnostic / economics,  standards
Venous Thrombosis / diagnosis*,  economics
Reg. No./Substance:
0/Reagent Kits, Diagnostic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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