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Cost-Effectiveness of Transcatheter Aortic Valve Replacement.
MedLine Citation:
PMID:  22308298     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Patients with symptomatic aortic stenosis have a poor prognosis, and medical therapy has little, if any, effect upon their natural history. Surgical aortic valve replacement (AVR) is risky, yet it appears to be effective in extending life expectancy and reducing symptoms due to aortic stenosis. In this setting, the development of transcatheter AVR appears to be a breakthrough technology, potentially offering the benefits of surgical AVR without the need for an operation(1). Early clinical experience with transcatheter AVR has been promising, and set the stage for a randomized trial to provide the definitive test of its efficacy. The concurrent PARTNER (Placement of AoRTic TraNscathetER Valves) trials(2,3) compared transcatheter AVR with medical therapy among patients at prohibitive risk of surgery (PARTNER Cohort B), and compared transcatheter and surgical AVR among patients at high, but acceptable risk of surgery (PARTNER Cohort A). The PARTNER Cohort B trial showed that transcatheter AVR reduced mortality by 50% among inoperable patients and also improved quality of life(2). Transcatheter AVR was clearly a great improvement over medical therapy among elderly patients (average age of 83 years) with inoperable aortic stenosis. (SELECT FULL TEXT TO CONTINUE).
Authors:
Mark A Hlatky; C Torrey Simons
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-3
Journal Detail:
Title:  Circulation     Volume:  -     ISSN:  1524-4539     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Stanford University School of Medicine, Stanford & VA Palo Alto Healthcare System, Palo Alto, CA.
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