| Cost-effectiveness of hybrid PET/CT for staging of non-small cell lung cancer. | |
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MedLine Citation:
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PMID: 21051648 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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METHODS: The study is based on 172 NSCLC patients from a prospective clinical study who underwent diagnostic, contrast-enhanced helical CT and integrated PET/CT. Imaging was performed at the University Hospital Ulm between May 2002 and December 2004. To calculate treatment costs, we differentiated among cost for diagnosis, cost for nonsurgical treatment according to the clinical diagnosis, and cost for surgical procedures according to the clinical tumor stage. RESULTS: The diagnostic effectiveness in terms of correct TNM staging was 40% (31/77) for CT alone and 60% (46/77) for PET/CT. For the assessment of resectability (tumor stages Ia-IIIa vs. IIIb-IV), 65 of 77 patients (84%) were staged correctly by PET/CT (CT alone, 70% [54/77]). The incremental cost-effectiveness ratios per correctly staged patient were $3,508 for PET/CT versus CT alone. The incremental cost-effectiveness ratios per quality-adjusted life year gained were $79,878 for PET/CT vs. CT alone, decreasing to $69,563 assuming a reduced loss of utility (0.10 quality-adjusted life years) due to surgical morbidity. CONCLUSION: Cost-effectiveness analyses showed that costs for PET/CT are within the commonly accepted range for diagnostic tests or therapies. Therefore, reimbursement of PET/CT for NSCLC staging can be also recommended from an economic point of view. |
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Authors:
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Jonas Schreyögg; Julia Weller; Tom Stargardt; Ken Herrmann; Christina Bluemel; Tobias Dechow; Gerhard Glatting; Bernd J Krause; Felix Mottaghy; Sven N Reske; Andreas K Buck |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 51 ISSN: 1535-5667 ISO Abbreviation: J. Nucl. Med. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-05 Completed Date: 2010-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 1668-75 Citation Subset: IM |
Affiliation:
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Institute of Health Economics and Health Care Management, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. schreyoegg@bwl.lmu.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carcinoma, Non-Small-Cell Lung / economics*, pathology*, radiography, radionuclide imaging Cost-Benefit Analysis Decision Making Female Humans Insurance, Health, Reimbursement / economics Lung Neoplasms / economics*, pathology*, radiography, radionuclide imaging Male Middle Aged Neoplasm Staging / economics* Positron-Emission Tomography / economics* Proportional Hazards Models Quality-Adjusted Life Years Sensitivity and Specificity Tomography, X-Ray Computed / economics* |
| Comments/Corrections | |
Comment In:
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J Nucl Med. 2010 Nov;51(11):1665-7
[PMID:
20956473
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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