| Cosolvent-free polymer gel dosimeters with improved dose sensitivity and resolution for x-ray CT dose response. | |
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MedLine Citation:
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PMID: 21386143 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This study reports new N-isopropylacrylamide (NIPAM) polymer gel recipes with increased dose sensitivity and improved dose resolution for x-ray CT readout. NIPAM can be used to increase the solubility of N, N'-methylenebisacrylamide (Bis) in aqueous solutions from approximately 3% to 5.5% by weight, enabling the manufacture of dosimeters containing up to 19.5%T, which is the total concentration of NIPAM and Bis by weight. Gelatin is shown to have a mild influence on dose sensitivity when gels are imaged using x-ray CT, and a stronger influence when gels are imaged optically. Phantoms that contain only 3% gelatin and 5 mM tetrakis hydroxymethyl phosphonium chloride are sufficiently stiff for dosimetry applications. The best cosolvent-free gel formulation has a dose sensitivity in the linear range (∼0.88 H Gy(-1)) that is a small improvement compared to the best NIPAM-based gels that incorporate isopropanol as a cosolvent (∼0.80 H Gy(-1)). This new gel formulation results in enhanced dose resolution (∼0.052 Gy) for x-ray CT readout, making clinical applications of this imaging modality more feasible. |
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Authors:
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J N M Chain; A Jirasek; L J Schreiner; K B McAuley |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-08 |
Journal Detail:
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Title: Physics in medicine and biology Volume: 56 ISSN: 1361-6560 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: - |
Other Details:
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Languages: ENG Pagination: 2091-2102 Citation Subset: - |
Affiliation:
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Department of Chemical Engineering, Queen's University, Kingston, K7L 3N6,Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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