Document Detail

The Cosmic Silence experiment: on the putative adaptive role of environmental ionizing radiation.
MedLine Citation:
PMID:  19169701     Owner:  NLM     Status:  MEDLINE    
Previously we reported that yeast and Chinese hamster V79 cells cultured under reduced levels of background environmental ionizing radiation show enhanced susceptibility to damage caused by acute doses of genotoxic agents. Reduction of environmental radiation dose rate was achieved by setting up an underground laboratory at Laboratori Nazionali del Gran Sasso, central Italy. We now report on the extension of our studies to a human cell line. Human lymphoblastoid TK6 cells were maintained under identical in vitro culture conditions for six continuous months, at different environmental ionizing radiation levels. Compared to "reference" environmental radiation conditions, we found that cells cultured in the underground laboratories were more sensitive to acute exposures to radiation, as measured both at the level of DNA damage and oxidative metabolism. Our results are compatible with the hypothesis that ultra-low dose rate ionizing radiation, i.e. environmental radiation, may act as a conditioning agent in the radiation-induced adaptive response.
M C Carbone; M Pinto; F Antonelli; F Amicarelli; M Balata; M Belli; L Conti Devirgiliis; L Ioannucci; S Nisi; O Sapora; L Satta; Giustina Simone; E Sorrentino; M A Tabocchini
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-24
Journal Detail:
Title:  Radiation and environmental biophysics     Volume:  48     ISSN:  0301-634X     ISO Abbreviation:  Radiat Environ Biophys     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-31     Completed Date:  2009-07-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0415677     Medline TA:  Radiat Environ Biophys     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  189-96     Citation Subset:  IM    
Museo Storico della Fisica e Centro Studi e Ricerche "Enrico Fermi", Rome, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antioxidants / metabolism
Background Radiation
Catalase / metabolism
Cell Line
Cell Proliferation / radiation effects
DNA Damage
Dose-Response Relationship, Radiation
Environmental Exposure
Lymphocytes / radiation effects*
Micronucleus Tests
Radiation, Ionizing*
Reg. No./Substance:
0/Antioxidants; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Appendiceal endometriosis presenting as perforated appendicitis: report of a case and review of the ...
Next Document:  Adipophilin distribution and colocalization with lipid droplets in skeletal muscle.